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the claim
The synaptic cleft is maintained through specific structural cell adhesion molecules
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
6 sources for · 0 against

The synaptic cleft and the structural integrity between pre- and postsynaptic terminals are maintained through specific trans-synaptic cell adhesion molecules.

Evidence for · 6
Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components
2022 · cited by 20
Paper 1 demonstrates that the presynaptic adhesion protein neurexin stabilizes postsynaptic structures and circuit connectivity.
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The analysis

The retrieved literature consistently supports the claim that synaptic adhesion molecules (such as neurexins, LRR-containing proteins, and dystroglycan) are responsible for establishing, bridging, and maintaining the structural architecture of the synaptic cleft. Multiple papers detail how these specific molecular interactions link pre- and postsynaptic compartments. Therefore, the verdict is SUPPORTED.

More for · 5
Intracellular protein complexes involved in synapse assembly in presynaptic neurons.
2019 · cited by 18
Paper 2 discusses how presynaptic membrane proteins like neurexins and LAR-RPTPs act as hubs that orchestrate synaptic adhesion pathways.
Structural insights into leucine-rich repeat-containing synaptic cleft molecules.
2019 · cited by 5
Paper 6 reviews how membrane receptor-like cell adhesion molecules and secreted proteins in the synaptic cleft mediate structural linkages between pre- and postsynaptic terminals.
Structural basis of calcium-dependent C1ql1/BAI3 assemblies in synaptic connectivity
2025 · cited by 3
Paper 7 highlights that cell adhesion molecules and associated secreted factors play pivotal roles in establishing and maintaining synaptic connectivity across the cleft.
Distinct functional domains of Dystroglycan regulate inhibitory synapse formation and maintenance in cerebellar Purkinje cells
2025 · cited by 3
Paper 8 shows that the cell adhesion molecule Dystroglycan is required for the formation and maintenance of synapses through specific extracellular and intracellular interactions.
Roles of synaptic cell adhesion molecules in the neuromodulatory systems.
2026 · cited by 1
Paper 10 notes that synaptic cell adhesion molecules are essential for synapse development and maintenance by physically linking presynaptic terminals to postsynaptic structures.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 8304 Aug 2026
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