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the claim
The sodium-potassium pump actively maintains cellular resting potential using ATP
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
3 sources for · 0 against

Multiple scientific reviews confirm that the sodium-potassium pump actively utilizes energy derived from ATP hydrolysis to transport ions and maintain cellular electrochemical and resting potentials.

Evidence for · 3
Na+/K+-ATPase: More than an Electrogenic Pump
2024 · cited by 67
Paper 2 states that the primary role of the sodium-potassium pump (Na+/K+-ATPase) is to transport sodium and potassium ions across the cell membrane using energy from ATP hydrolysis, creating and maintaining an electrochemical gradient.
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The analysis

The claim states that the sodium-potassium pump actively maintains cellular resting potential using ATP. Retrieved papers such as [2], [5], and [10] explicitly discuss the Na+/K+-ATPase pump utilizing ATP hydrolysis to transport sodium and potassium ions and maintain ionic gradients/homeostasis. No papers refute this fundamental physiological fact.

More for · 2
A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developments
2024 · cited by 25
Paper 5 reviews how the Na+,K+-ATPase plays a central role in Na+/K+ homeostasis through rates of ATP hydrolysis.
Factors that influence the Na/K-ATPase signaling and function
2025 · cited by 11
Paper 10 notes that the transmembrane Na/K-ATPase utilizes energy from ATP hydrolysis to execute its pumping function.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Phosphorylation of Na,K-ATPase by Protein Kinase C at Ser18 Occurs in Intact Cells but Does Not Result in Direct Inhibition of ATP Hydrolysis*peer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. Na+/K+-ATPase: More than an Electrogenic Pumppeer-reviewedsupports
  4. Sodium and potassium fluxes and membrane potential of human neutrophils: evidence for an electrogenic sodium pump.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Gastric Hypersecretory States: Investigation and Management.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. A century of exercise physiology: effects of muscle contraction and exercise on skeletal muscle Na+,K+-ATPase, Na+ and K+ ions, and on plasma K+ concentration—historical developmentspeer-reviewedsupports
  7. Astrocyte Kir4.1 expression level territorially controls excitatory transmission in the brain.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Interdependence of cellular and network properties in respiratory rhythm generation.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Effect of Fe3+ on Na,K-ATPase: Unexpected activation of ATP hydrolysis.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Factors that influence the Na/K-ATPase signaling and functionpeer-reviewedsupports
  12. Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → SUPPORTED · 8606 Aug 2026
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