The six-layer model remains the most accepted structural framework of the mammalian neocortex
the verdict
SUPPORTED
the evidence backs this
confidence 92/100
The six-layered structural organization of the neocortex is well established in neuroanatomy and comparative neuroscience as a defining feature of the mammalian brain.
Evidence for · 5
Neural progenitors, neurogenesis and the evolution of the neocortex
2014 · cited by 605
Discusses the neocortex as the hallmark structure of the mammalian brain with layered features.
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More for · 4
Laminar Organization of Thalamic Projections to the Rat Neocortex
1980 · cited by 486
Details the classic laminar organization of the mammalian neocortex into distinct layers.
Single-cell genomics of the mouse olfactory cortex reveals contrasts with neocortex and ancestral signatures of cell type evolution.
2025 · cited by 3
Compares the typical six-layered mammalian neocortex against simpler three-layered cortical areas.
Adaptive evolution of gene regulatory networks in mammalian neocortex.
2026 · cited by 2
Highlights the evolutionary transition from single-layered ancestral structures to the multi-layered mammalian neocortex.
Role of mechanical morphogenesis in the development and evolution of the neocortex
2018 · cited by 2
Refers to the outermost layer of the mammalian cerebrum as the defining structural neocortex.