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the claim
The number of tRNA molecules is smaller than the number of codons due to wobble pairing
the verdict
SUPPORTED
the evidence backs this
confidence 75/100

The number of tRNA molecules is smaller than the number of codons because wobble base pairing allows single tRNAs to recognize multiple synonymous codons.

Evidence for · 2
Regulation of tRNA expression during the social cycle of the amoeba Dictyostelium discoideum.
2026 · cited by 0
Paper 4 notes that genomes can escape tight translational selection because wobble positioning allows a smaller set of tRNA anticodons to decode multiple codons.
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More for · 1
Reconsideration of codon-anticodon wobble pairings in translation: decoding tables
2023 · cited by 0
Paper 10 details how wobble pairings across diverse organisms allow tRNAs to decode multiple degenerate codons, explaining the reduced number of tRNAs compared to codons.
The paper trail · every fact has a biography
first checked01 Aug 2026
judged → SUPPORTED · 7501 Aug 2026
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