Biological systems, including human and mammalian cells, possess endogenous signaling pathways (such as Nrf2-mediated responses) that adapt to and build tolerance against oxidative stress through a process akin to hormesis.
The retrieved literature consistently demonstrates that cells and tissues have evolved sophisticated adaptive stress response mechanisms (such as redox signaling via Nrf2) that upregulate antioxidant defenses and improve cellular resilience following exposure to oxidative stress or hormetic stimuli.