The gauche effect is explained by hyperconjugation and electrostatic interactions
the verdict
SUPPORTED
the evidence backs this
confidence 77/100
The gauche effect in fluorinated compounds is predominantly explained by a combination of hyperconjugative electron delocalization and electrostatic interactions.
Evidence for · 3
Origami with small molecules: exploiting the C-F bond as a conformational tool.
2025 · cited by 1
Paper 3 notes that the C-F bond aligns predictably due to stereoelectronic effects including hyperconjugation and electrostatic attraction.
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More for · 2
Revisiting the Conformational Equilibrium of 1,1,2-Trifluoroethane and 1,1,2,2-Tetrafluoroethane: An NBO Study.
2025 · cited by 0
Paper 4 investigates the conformational preferences of fluorinated ethanes through hyperconjugation and electrostatic frameworks.
Conformational analysis of difluoromethylornithine: factors influencing its gas-phase and bioactive conformations.
2026 · cited by 0
Paper 5 confirms that the fluorine gauche effect in DFMO arises primarily from hyperconjugative stabilization and is intensified by electrostatic interactions.