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the claim
The CI repressor functions as both an activator and a repressor of the PRM promoter in lambda phage.
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
2 sources for · 0 against

The CI repressor of lambda phage functions dually, acting as both an activator and a repressor of the PRM promoter to regulate the genetic switch.

Evidence for · 2
Tunable Temperature-Sensitive Transcriptional Activation Based on Lambda Repressor.
2022 · cited by 24
Paper [3] explicitly notes that natively, the CI repressor serves as both a repressor and activator of transcription at the natural PRM promoter.
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The analysis

Both retrieved papers [3] and [9] explicitly state that the CI repressor acts as a dual regulator, serving as both a repressor and an activator of the PRM promoter in lambda phage. There are no papers contradicting this claim, leading to a verdict of SUPPORTED.

More for · 1
Research on phage λ: a lucky choice.
2024 · cited by 5
Paper [9] details how the CI repressor autoregulates repression of phage lytic promoters as well as activation of the lysogenic promoter.
Everything we examined (12)
  1. The hidden life of integrative and conjugative elements.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. Bacteriophage self-counting in the presence of viral replication.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Tunable Temperature-Sensitive Transcriptional Activation Based on Lambda Repressor.peer-reviewedsupports
  5. Evolution of Regulated Transcription.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. The role of repressor kinetics in relief of transcriptional interference between convergent promoters.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Phage lambda Cro protein and cI repressor use two different patterns of specific protein-DNA interactions to achieve sequence specificity in vivo.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Bacteriophage λ RexA and RexB functions assist the transition from lysogeny to lytic growth.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Recent Synthetic Biology Approaches for Temperature- and Light-Controlled Gene Expression in Bacterial Hosts.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Research on phage λ: a lucky choice.peer-reviewedsupports
  11. An activator regulates the DNA damage response and anti-phage defense networks in Moraxellaceae.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. CF2H: a cell-free two-hybrid platform for rapid protein binder screening.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 7205 Aug 2026
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