The brain undergoes specific functional reorganization after a hemispherectomy
Clinical and neuroimaging studies consistently demonstrate that the human brain undergoes substantial, specific functional reorganization within the remaining hemisphere following a hemispherectomy.
The claim is specific, empirical, and well-supported by multiple peer-reviewed studies examining functional reorganization in patients who have undergone hemispherectomy. The retrieved literature (specifically papers 1, 4, 5, and 9) provides direct evidence of large-scale plasticity and pathway-specific functional redistribution following the procedure. There is no evidence refuting the claim.
V. Ayzenberg, M. Granovetter, Sophia Robert, Christina M Patterson, M. Behrmann. Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy. 2023. https://doi.org/10.1016/j.dcn.2023.101323
Demonstrates that ventral and dorsal visual pathways undergo differential functional reorganization following childhood hemispherectomy.
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Vladislav Ayzenberg, Michael C. Granovetter, Sophia Robert, Christina Patterson, Marlene Behrmann. Differential functional reorganization of ventral and dorsal visual pathways following childhood hemispherectomy. 2023. https://doi.org/10.1101/2023.08.03.551494
Shows that visual pathways reorganize to the contralateral hemisphere after hemispherectomy, with the ventral pathway displaying greater plasticity than the dorsal pathway.
Luis F Seoane, Ricard Solé. Modeling brain reorganization after hemispherectomy. 2020. https://doi.org/10.1101/2020.12.25.424412
Explains that brain reorganization after hemispherectomy represents a remarkable example of large-scale plasticity where the remaining hemisphere assumes processing burdens.
Moksada Regmi, Qiang Yang, Xiangqi Wang, Shikun Liu, Ying Xiong, Junyi Liu, Jun Yang, Chenlong Yang. Functional recovery and neuroplasticity post-hemispherectomy in humans.. 2026. https://doi.org/10.1016/j.neures.2026.105051
Synthesizes evidence showing that post-hemispherectomy functional recovery relies on alternative pathways and cortical recruitment across sensory, motor, and linguistic domains.
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