The brain immediately detects when thirst is quenched via neural feedback from the gut and mouth
the verdict
SUPPORTED
the evidence backs this
confidence 90/100
The brain immediately detects when thirst is quenched through rapid neural and preabsorptive feedback from the mouth and gastrointestinal tract, long before the ingested water is absorbed into the bloodstream.
Evidence for · 5
Thirst neurons anticipate the homeostatic consequences of eating and drinking.
2016 · cited by 230
Demonstrates that thirst-promoting neurons in the subfornical organ respond rapidly to neural feedback from the oral cavity during drinking to anticipate and adjust fluid balance.
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More for · 4
Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger.
2020 · cited by 109
Reviews how individual appetite circuits use ingestion-related satiation signals to rapidly quench thirst.
Layers of signals that regulate appetite.
2020 · cited by 38
Explains that eating and drinking generate sequential layers of feedback signals from different tissues that converge in the brain to regulate thirst.
The neurobiology of thirst and salt appetite.
2024 · cited by 13
Discusses how motivational drives for water are rapidly quenched by preabsorptive signals from ingestion before changes in blood osmolality occur.
The Neurocircuitry of fluid satiation.
2018 · cited by 12
Highlights that thirst is quenched tens of minutes before water reaches circulation, driven by preabsorptive inputs from oropharyngeal and gastrointestinal regions.