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the claim
The adult human heart preferentially metabolizes fatty acids over glucose for energy
the verdict
SUPPORTED
the evidence backs this
confidence 88/100

The healthy adult human heart relies predominantly on fatty acid oxidation over glucose to meet its continuous, high energy demands.

Evidence for · 4
Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes
2019 · cited by 141
As cardiomyocytes mature during development, fatty acid beta-oxidation becomes a key energy source to meet the adult heart's high energy demand.
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More for · 3
Sphingolipid metabolism controls mammalian heart regeneration.
2024 · cited by 61
The utilization of lipids as energy substrates after birth characterizes adult cardiomyocyte metabolism.
Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms.
2026 · cited by 1
The adult heart depends heavily on lipid uptake and utilization for proper function and energy production.
YAP Induces a Prorenewal Metabolic State in Cardiomyocytes.
2026 · cited by 1
Maturing cardiomyocytes undergo a metabolic shift from predominantly glycolysis in the neonatal state to increased fatty acid oxidation in the mature state.
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first checked01 Aug 2026
judged → SUPPORTED · 8801 Aug 2026
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