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the claim
Testosterone and anabolic steroid injections increase the risk of tendon rupture
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
3 sources for · 0 against

Clinical reviews and large retrospective studies consistently demonstrate that testosterone and anabolic-androgenic steroid use increases the risk of musculoskeletal complications, specifically tendon injuries and ruptures.

Evidence for · 3
Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement.
2014 · cited by 325
This scientific statement links performance-enhancing drug use, including testosterone and anabolic steroids, to various musculoskeletal disorders.
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The analysis

The retrieved literature contains specific clinical studies and reviews directly evaluating the relationship between testosterone replacement therapy or anabolic steroid use and tendon injuries. Paper [3] provides strong direct evidence via a large retrospective cohort showing increased odds of Achilles tendon injury and surgery with testosterone therapy, while paper [10] reviews how anabolic-androgenic steroids disrupt collagen balance and increase tendon rupture risk. Paper [0] broadly supports the link to musculoskeletal disorders. No papers refute the claim.

More for · 2
Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis
2023 · cited by 16
This matched retrospective analysis found that testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery.
Impact of Anabolic Steroids on Tendons: A Narrative Review
2025 · cited by 4
This narrative review concludes that anabolic-androgenic steroids weaken collagen structure and elasticity, thereby increasing the risk of tendon rupture.
Everything we examined (12)
  1. Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement.peer-reviewedsupports
  2. Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. Shear wave elastography to assess stiffness of the human ovary and other reproductive tissues across the reproductive lifespan in health and disease†.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysispeer-reviewedsupports
  5. Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Pathophysiology, Clinical Heterogeneity, and Therapeutic Advances in Amyotrophic Lateral Sclerosis: A Comprehensive Review of Molecular Mechanisms, Diagnostic Challenges, and Multidisciplinary Management Strategies.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadismpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Testosterone Replacement Therapy in the Treatment of Depression.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Pectoralis major rupture in body builders: a case series including anabolic steroid use.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Growth hormone and aging: a clinical review.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Impact of Anabolic Steroids on Tendons: A Narrative Reviewpeer-reviewedsupports
  12. Abuse of Anabolic-Androgenic Steroids as a Social Phenomenon and Medical Problem-Its Potential Negative Impact on Reproductive Health Based on 50 Years of Case Report Analysis.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 9105 Aug 2026
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