Symmetrically substituted biphenyl derivatives, particularly those with bulky ortho-substituents that restrict rotation about the central C-C bond, frequently exhibit axial chirality (atropisomerism).
Evidence for · 3
Influence of Substituents on the Rotational Energy Barrier of Axially Chiral Biphenyls, II
1996 · cited by 66
Paper [0] investigates the rotational energy barriers of 2,2'-disubstituted and symmetrically substituted biphenyl derivatives (such as 2,2'-bis(trifluoromethyl)biphenyl and 2,2'-diisopropylbiphenyl), confirming their axially chiral nature.
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More for · 2
An Enantioselective Suzuki-Miyaura Coupling To Form Axially Chiral Biphenols.
2022 · cited by 30
Paper [2] discusses the prevalence and significance of axially chiral atropisomeric 2,2'-biphenols.
Development of diverse adjustable axially chiral biphenyl ligands and catalysts.
2023 · cited by 2
Paper [7] describes the development and application of axially chiral [1,1'-biphenyl]-2,2'-diol ligands and catalysts.