Comparative effects of nondepolarizing muscle relaxants on succinycholine-induced fasciculations and postoperative pain. The effectiveness of pancuronium (1.0 to 1.5 mg), d-tubocurarine (3 mg), and gallamine (20 mg) administered three minutes before succinylcholine (1 mg/kg) in preventing muscle fasciculations and postoperative muscle pains was compared in 100 patients. Pretreatment with pancuronium abolished fasciculations and produced rapid and excellent muscle relaxation for endotracheal intubation. Both d-tubocurarine (dTc) and gallamine administered prior to succinylcholine (SCh) were inconsistent in prevention fasciculations. Muscle relaxation was significantly delayed in onset, shorter in duration, and was inadequate for intubation in the majority of patients. The 45% incidence of postoperative muscle pains in the control group decreased after pretreatment with gallamine, dTc, and pancuronium to 20%, 15%, and less than 5%, respectively. It was concluded from the present study that pancuronium is superior to dTc and gallamine for preventing SCh-induced fasciculations and postoperative muscle pains without compromising the muscle relaxation for intubation.

Effect of fazadinium (Fazadon) on muscle fasciculations induced by succinylcholine. The effects on muscle fasciculations and ease of tracheal intubation of pretreatment with fazadinium before administration of succinylcholine were evaluated in 85 patients. Four dose levels of fazadinium evaluated were 0.05 mg . kg-1, 0.075 mg . kg-1, 0.10 mg . kg-1 and 0.15 mg . kg-1. The 0.05 mg . kg-1 dose did not always prevent succinylcholine-induced muscle fasciculations. The 0.15 mg . kg-1 dose gave poor conditions for tracheal intubation and was therefore discontinued. The 0.075 mg . kg-1 dose seemed optimal. Most patients felt transient pain at the site of the injection during administration of fazadinium, and many had a sensation of drowsiness. Published in Canadian Anaesthetists' Society journal (1981)

Background: Succinylcholine gained widespread use rapidly because of its onset is very fast and duration is ultra-short. However, its utility is compromised due to its adverse effects. succinylcholine-induced muscle fasciculations, myalgia is attenuated and prevented by use of multiple drugs. Aims and objectives: To evaluate the rapid precurarization technique using rocuronium and atracurium induced rapid precurarization on succinylcholine induced rapid fasciculations, post-operative myalgias and intubating conditions. Materials and Methods: A comparative observational study comprising of 60 p

Succinylcholine is a quaternary ammonium ion that is the bis-choline ester of succinic acid. It has a role as a muscle relaxant, a neuromuscular agent and a drug allergen. It is a quaternary ammonium ion and a succinate ester.

Aim: To compare rocuronium 0.9mg/kg and succinylcholine 2 mg/kg for tracheal intubation at 60 seconds after the administration of muscle relaxants in patients undergoing elective surgeries. Methodology: A randomized controlled study conducted on Department of Anesthesia, Bhagwan Mahavir institute of Medical Sciences, Pawapuri, Nalanda, Bihar, India for one year. 50 adult patients American society of anesthesiologist grade I and II patients. All patients underwent pre-anesthetic evaluation and relevant investigations one day prior to surgery. All patients underwent pre-anesthetic evaluation pri

etomidate. Commonly used neuromuscular blocking agents used include succinylcholine and rocuronium. The neuromuscular blocking agents paralyze all of the