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the claim

Substance withdrawal can trigger grand mal seizures

the verdict

SUPPORTED

the evidence backs this

confidence 94/100

Substance withdrawal, particularly from alcohol or sedatives, lowers the seizure threshold and is well-documented to trigger acute symptomatic seizures, including generalized tonic-clonic (grand mal) seizures.

Evidence for · 3

Recommendation for a definition of acute symptomatic seizure

2009 · cited by 913

Identifies drug or alcohol withdrawal as a recognized cause of acute symptomatic seizures.

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More for · 2

Alcohol and Marijuana: Effects on Epilepsy and Use by Patients with Epilepsy

2001 · cited by 178

Notes that alcohol withdrawal lowers the seizure threshold and is a serious risk for seizures in chronic abusers.

THE HORMONAL RESPONSES TO GENERALIZED TONIC-CLONIC SEIZURES

1984 · cited by 106

Includes clinical study subjects experiencing generalized tonic-clonic seizures specifically arising from alcohol withdrawal.

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first checked02 Aug 2026

judged → SUPPORTED · 9402 Aug 2026

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