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the claim

SSRIs function by blocking the reuptake of serotonin in the synaptic cleft

the verdict

SUPPORTED

the evidence backs this

confidence 91/100

Selective serotonin reuptake inhibitors (SSRIs) exert their pharmacological effects by blocking the reuptake of serotonin at the synapse, thereby increasing extracellular serotonin concentrations.

Evidence for · 2

Selective Serotonin Reuptake Inhibitors and Adverse Effects: A Narrative Review

2021 · cited by 358

Paper 0 explicitly states that the primary mechanism of action of SSRIs is to inhibit the presynaptic reuptake of serotonin at the serotonin transporter, increasing synaptic serotonin levels.

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More for · 1

Effects of selective serotonin reuptake inhibitors on endocrine system (Review)

2024 · cited by 21

Paper 3 confirms that SSRIs function by inhibiting serotonin reuptake, which raises serotonin levels in the synaptic cleft.

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first checked01 Aug 2026

judged → SUPPORTED · 9101 Aug 2026

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