Clinical literature and meta-analyses consistently support the finding that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) cause sexual side effects, particularly orgasmic dysfunction and anorgasmia.
Evidence for · 5
Post-SSRI sexual dysfunction: barriers to quantifying incidence and prevalence
2024 · cited by 27
This study discusses post-SSRI sexual dysfunction, noting that SSRI-induced sexual side effects characteristically include weak or pleasureless orgasm.
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More for · 4
Post-SSRI sexual dysfunction and SSRI induced sexual dysfunction - literature review
2023 · cited by 4
This review highlights sexual dysfunction as a very common side effect of selective serotonin reuptake inhibitors that can occur both during and after treatment.
Sexual dysfunction associated with selective serotonin reuptake inhibitors in adults with depression: a systematic review and meta-analysis.
2026 · cited by 1
This systematic review and meta-analysis of randomized controlled trials establishes that SSRIs are significantly associated with an increased risk of orgasmic dysfunction.
Antidepressant-Induced Sexual Dysfunction in Adults: A Targeted Scoping Review and Clinical Update.
2026 · cited by 0
This scoping review notes that antidepressant-induced sexual dysfunction is a common and under-recognized adverse effect particularly associated with SSRIs and SNRIs.
Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor use and sexual dysfunction: a pharmacovigilance analysis.
2026 · cited by 0
This pharmacovigilance analysis demonstrates that sexual adverse events, including sexual dysfunction, are associated with various SSRIs and SNRIs in real-world data.