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the claim

Specific mechanisms bind the histone code with alternative splicing

the verdict

SUPPORTED

the evidence backs this

confidence 75/100

Current molecular evidence demonstrates that specific histone modifications directly regulate and induce alternative splicing events through identifiable adaptor mechanisms.

Evidence for · 2

The role of histone modifications in the regulation of alternative splicing during epithelial-to-mesenchymal transition

cited by 0

The study uses CRISPR/dCas9 systems to directly modify specific histone marks on alternative exons, proving that these marks are sufficient to induce alternative splicing changes during epithelial-to-mesenchymal transition.

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More for · 1

Alternative splicing links histone modifications to stem cell fate decision

2017 · cited by 0

The paper identifies specific mechanisms, such as the PSIP1/SRSF1 adaptor linking H3K36me3 to exon skipping in PBX1, demonstrating a direct connection between histone modifications and alternative splicing.

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first checked01 Aug 2026

judged → SUPPORTED · 7501 Aug 2026

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