Specific genetic mutations and loci are associated with exceptional human longevity
the verdict
SUPPORTED
the evidence backs this
confidence 67/100
Multiple large-scale genomic and meta-analytic studies demonstrate that specific genetic variants, loci, and mutation burdens are reliably associated with exceptional human longevity.
Evidence for · 7
Meta-analysis of genetic variants associated with human exceptional longevity
2013 · cited by 78
A meta-analysis confirms that multiple specific genetic variants and combinations differentiate centenarians from non-centenarians.
Evidence against · 1
Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.
2024 · cited by 2
A study of the Sardinian Blue Zone population found no significant deviation in most tested common longevity polymorphisms, suggesting certain markers do not universally apply across all isolated populations.
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More for · 6
Rare genetic coding variants associated with human longevity and protection against age-related diseases
2021 · cited by 44
Whole-exome sequencing of centenarians identifies rare coding variants in conserved longevity pathways like insulin signaling and AMPK.
Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity
2012 · cited by 37
Specific single-nucleotide polymorphisms in the ADRB2 gene are shown to be significantly associated with enhanced human longevity.
Genetic Variants in PVRL2-TOMM40-APOE Region Are Associated with Human Longevity in a Han Chinese Population
2014 · cited by 36
Variants in the PVRL2-TOMM40-APOE locus demonstrate significant associations with human longevity in population studies.
Identification of new genetic variants of HLA-DQB1 associated with human longevity and lipid homeostasis—a cross-sectional study in a Chinese population
2017 · cited by 23
Specific new single nucleotide polymorphisms of HLA-DQB1 are identified as being associated with longevity and lipid homeostasis.
Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.
2024 · cited by 10
Gene-level burden analysis reveals specific genes with depleted loss-of-function mutations that act as longevity genes.
A centenarian single nucleotide polymorphism in collagen gene COL25A1 promotes longevity in C. elegans.
2025 · cited by 1
A centenarian-associated SNP in COL25A1 is shown to influence furin cleavage and promote longevity.