Specific chemical properties make LSD highly psychoactive
the verdict
SUPPORTED
the evidence backs this
confidence 92/100
Specific chemical and structural properties allow LSD to bind with high affinity and stereospecificity to serotonin receptors, directly underlying its potent psychoactivity.
Evidence for · 5
Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.
1976 · cited by 488
Paper 0 establishes the high-affinity stereospecific binding sites for LSD in the rat brain, demonstrating its structural specificity at serotonin-related receptors.
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More for · 4
Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation.
1993 · cited by 142
Paper 1 uses site-directed mutagenesis to identify specific amino acids (such as Asp-155) necessary for high-affinity LSD binding at the 5-HT2 receptor.
Serotonin receptor binding sites affected differentially by guanine nucleotides.
1979 · cited by 109
Paper 2 demonstrates how the mixed agonist-antagonist profile of LSD interacts uniquely with brain serotonin receptors compared to endogenous neurotransmitters.
Stereospecific receptor sites for d-lysergic acid diethylamide in rat brain: effects of neurotransmitters, amine antagonists, and other psychotropic drugs.
1976 · cited by 51
Paper 3 analyzes the stereospecific high-affinity receptor sites for d-LSD in the rat brain, highlighting specific binding characteristics.
Antagonism of 5-hydroxytryptamine2 receptor-mediated phosphatidylinositol turnover by d-lysergic acid diethylamide.
1988 · cited by 34
Paper 5 analyzes the precise molecular interactions and antagonism of d-LSD at 5-HT2 receptors using radioligand binding and biochemical assays.