Smoking marijuana is detrimental to long-term health
the verdict
SUPPORTED
the evidence backs this
confidence 85/100
Multiple systematic reviews and empirical studies indicate that long-term cannabis use is associated with adverse health outcomes, including respiratory symptoms, increased risk of anxiety disorders, structural brain changes in adolescents, and biomarkers of accelerated biological aging.
Evidence for · 4
Cannabis Use and Prospective Long-Term Association with Anxiety: A Systematic Review and Meta-Analysis of Longitudinal Studies: Usage du cannabis et association prospective à long terme avec l’anxiété: une revue systématique et une méta-analyse d’études longitudinales
2020 · cited by 44
This systematic review and meta-analysis indicates that cannabis use is significantly associated with increased odds of developing anxiety conditions over the long term.
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More for · 3
Cannabis use and its impact on respiratory physiology and lung cancer risk: Mechanistic and epidemiological insights (Review).
2025 · cited by 1
This review highlights that chronic cannabis smoking is associated with respiratory symptoms resembling chronic bronchitis and impaired alveolar macrophage function, pointing to long-term pulmonary health concerns.
Current marijuana use is associated with lower circulating α-Klotho levels in US adults even after adjusting for tobacco use: A national cross-sectional analysis of NHANES.
2025 · cited by 1
This national cross-sectional analysis found that marijuana use is associated with lower circulating levels of the longevity-associated protein alpha-Klotho, suggesting a potential link to accelerated biological aging.
How adolescent cannabis use reshapes the developing brain - a systematic review.
2026 · cited by 0
This systematic review reports that adolescent cannabis use is associated with structural brain changes, elevated addiction risk, and various long-term cognitive and functional impairments.