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the claim
Single-stranded RNA binds to double-stranded DNA via Hoogsteen base pairing to form triplex structures
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
2 sources for · 0 against

Single-stranded RNA can bind to double-stranded DNA via Hoogsteen base pairing to form triplex structures, a mechanism supported by literature on non-canonical nucleic acid interactions and DNA-RNA triplex predictions.

Evidence for · 2
2019 · cited by 2
The study discusses nucleic acid structures where a single-stranded nucleic acid molecule interacts via Hoogsteen bonds with a double helix.
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The analysis

The retrieved papers, particularly references [7] and [9], directly state that single-stranded nucleic acid or RNA molecules interact via Hoogsteen bonds with DNA double helices to form triplex structures (DNA-RNA triple helices). Therefore, the claim is supported by the literature.

More for · 1
2025 · cited by 1
The paper notes that intranuclear noncoding RNAs form DNA-RNA triple helices through the base pairing of target sites and oligonucleotides using canonical Hoogsteen rules.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 7804 Aug 2026
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