Side effects compromise the blinding in clinical studies
the verdict
SUPPORTED
the evidence backs this
confidence 78/100
Clinical trial evidence confirms that noticeable side effects can compromise study blinding by revealing treatment allocations to participants and personnel.
Evidence for · 3
Specific-class Skin Side-effects of Drugs Might Compromise Blinding in Randomized Controlled Trials
2023 · cited by 2
Demonstrates that specific class skin side-effects of drugs can compromise blinding in randomized controlled trials.
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More for · 2
Safety and tolerability of the ACE-inhibitor lisinopril among Nigerian adults with HIV: preliminary pilot data from a randomized clinical trial.
2026 · cited by 0
Notes that adverse events like persistent cough and angioedema led to unblinding in participants taking lisinopril.
Overcoming blinding confounds in psychedelic randomized controlled trials using biomarker driven causal mediation analysis
2023 · cited by 0
Highlights how distinctive psychoactive side effects cause unblinding and expectancy effects in psychedelic randomized controlled trials.