Seizures result from an excess of electrical current in the brain
the verdict
SUPPORTED
the evidence backs this
confidence 68/100
Seizures are widely understood to result from abnormal, excessive electrical activity and neuronal hyperexcitability in the brain, driven largely by imbalances in excitatory and inhibitory neurotransmission.
Evidence for · 4
Glutamatergic Mechanisms Associated with Seizures and Epilepsy
2015 · cited by 435
Highlights that epilepsy is broadly characterized by aberrant neuronal excitability and elevations in the primary excitatory neurotransmitter glutamate.
Evidence against · 1
Heterogeneous neuronal firing patterns during interictal epileptiform discharges in the human cortex
2010 · cited by 201
Demonstrates that interictal epileptiform activity is complex, involving diverse neuronal firing patterns rather than a simple paroxysm of uniform hypersynchronous excitation.
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More for · 3
The Role of Glutamatergic Neurotransmission in the Pathophysiology of Alcoholism
1998 · cited by 387
Explains how abrupt withdrawal leads to a hyperexcitable state driven by excitatory neurotransmission that causes seizures.
Biomolecular mechanisms of epileptic seizures and epilepsy: a review
2023 · cited by 145
Defines epilepsy as a neurological disease caused by abnormal electrical activity and neuronal hyperexcitability in the brain.
Pathophysiology of epilepsy.
2000 · cited by 132
Identifies increased neuronal excitability, synchronicity, and an imbalance in neurotransmitter systems as key mechanisms underlying seizures.