Seborrheic dermatitis is influenced by fungi and environmental factors
Multiple clinical and microbiological studies support the role of Malassezia fungi and skin microbiome alterations in the development and severity of seborrheic dermatitis.
The retrieved papers consistently demonstrate that Malassezia species (such as M. globosa and M. restricta) and microbial dysbiosis play critical roles in the pathogenesis of seborrheic dermatitis, supporting the claim.
Mahnaz Gholami, Fatemeh Mokhtari, Rasoul Mohammadi. Identification of Malassezia species using direct PCR-sequencing on clinical samples from patients with pityriasis versicolor and seborrheic dermatitis. 2020. https://doi.org/10.18502/cmm.6.3.3984
Identifies Malassezia species such as M. globosa and M. restricta as key etiologic and flora agents associated with seborrheic dermatitis.
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Rušanac A, Škibola Z, Matijašić M, Čipčić Paljetak H, Perić M. Microbiome-Based Products: Therapeutic Potential for Inflammatory Skin Diseases.. 2025. https://doi.org/10.3390/ijms26146745
Notes that skin microbiome dysbiosis, including shifts in fungal populations, contributes to inflammatory skin conditions like seborrheic dermatitis.
Lee CH, Min M, Jin SS, Sivamani RK. Skin Microbiome Shifts in Various Dermatological Conditions.. 2025. https://doi.org/10.3390/jcm14176137
Demonstrates that the skin microbiome is significantly altered in various dermatological diseases, reflecting environmental and microbial shifts.
Davient B, Rikhraj JK, Ravikrishnan A, Rozario P, Leong C, Mohamed Naim AN, Chan N, Common J, Chambers JC, Yew YW, Loh M, Nagarajan N, Dawson TL. <i>Malassezia</i> and the Asian menopausal skin. 2025. https://doi.org/10.1101/2025.06.24.660996
Shows that changes in skin ecological niches and Malassezia dynamics trigger pro-inflammatory responses resembling seborrheic dermatitis.
Χριστόφορος Βλάχος. The participation of Malassezia genus in the pathobiology of seborrheic dermatitis. https://doi.org/10.12681/eadd/42427
Explores the pathobiological role of the Malassezia genus and lipid-metabolizing enzymes in seborrheic dermatitis.
Prasanna Honnavar, Arunaloke Chakrabarti, Sunil Dogra, PVM Lakshmi, Shivaprakash Rudramurthy. S9.5d Genotyping of <i>Malassezia</i> species from seborrheic dermatitis/dandruff patients. 2022. https://doi.org/10.1093/mmy/myac072.s9.5d
Links specific genotypes of Malassezia restricta and M. arunalokei to moderate-to-severe forms of seborrheic dermatitis/dandruff.
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