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the claim
Seasonal coronaviruses target specific cellular receptors to cause winter colds
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
3 sources for · 0 against

Seasonal human coronaviruses, which cause common winter colds, rely on specific viral spike proteins to bind target cellular receptors for host entry.

Evidence for · 3
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
2005 · cited by 739
Demonstrates that seasonal human coronavirus NL63 utilizes specific cellular receptors (ACE2) for entry.
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The analysis

The retrieved literature confirms that seasonal coronaviruses (such as NL63, 229E, OC43, and HKU1) cause common cold symptoms and interact with specific host cell receptors via their spike proteins to establish infection.

More for · 2
Coronaviruses and SARS-COV-2
2020 · cited by 393
Notes that seasonal coronaviruses like 229E, NL63, HKU1, and OC43 are endemic and typically cause common cold symptoms.
Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229E
2020 · cited by 2
Discusses seasonal coronaviruses OC43 and 229E, highlighting adaptive evolution in their spike proteins which mediate receptor binding and host infection.
The paper trail · every fact has a biography
first checked31 Jul 2026
judged → SUPPORTED · 9331 Jul 2026
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