Seasonal coronaviruses target specific cellular receptors to cause winter colds
the verdict
SUPPORTED
the evidence backs this
confidence 93/100
Seasonal human coronaviruses, which cause common winter colds, rely on specific viral spike proteins to bind target cellular receptors for host entry.
Evidence for · 3
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry
2005 · cited by 739
Demonstrates that seasonal human coronavirus NL63 utilizes specific cellular receptors (ACE2) for entry.
See more details
More for · 2
Coronaviruses and SARS-COV-2
2020 · cited by 393
Notes that seasonal coronaviruses like 229E, NL63, HKU1, and OC43 are endemic and typically cause common cold symptoms.
Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229E
2020 · cited by 2
Discusses seasonal coronaviruses OC43 and 229E, highlighting adaptive evolution in their spike proteins which mediate receptor binding and host infection.