Saliva contains diagnostic biomarkers for various systemic diseases
the verdict
SUPPORTED
the evidence backs this
confidence 94/100
Multiple studies and reviews demonstrate that human saliva contains a wealth of molecular components, including proteins, RNAs, and exosomes, which serve as non-invasive diagnostic biomarkers for various systemic and local diseases.
Evidence for · 11
Biomarkers of Cardiovascular Disease
2006 · cited by 1,203
Identifies biomarkers as tools for diagnosing disease conditions promptly and accurately.
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More for · 10
Salivary microRNA: Discovery, Characterization, and Clinical Utility for Oral Cancer Detection
2009 · cited by 839
Shows that salivary microRNAs can be used for oral cancer detection.
Salivary Biomarkers: Toward Future Clinical and Diagnostic Utilities
2013 · cited by 651
Discusses the significance of saliva as a source of indicators for local, systemic, and infectious disorders.
Salivary Transcriptome Diagnostics for Oral Cancer Detection
2004 · cited by 624
Demonstrates salivary transcriptome diagnostics successfully for oral cancer detection.
Salivary Proteomics for Oral Cancer Biomarker Discovery
2008 · cited by 547
Finds that patient-based saliva proteomics provides a promising approach for biomarker discovery.
Human body fluid proteome analysis
2006 · cited by 529
Reviews body fluid proteome analysis for human disease biomarker discovery across various fluids.
The Proteomes of Human Parotid and Submandibular/Sublingual Gland Salivas Collected as the Ductal Secretions
2008 · cited by 444
Notes that components found in plasma are also present in saliva, allowing for diagnostic translation.
Current Developments in Salivary Diagnostics
2010 · cited by 393
Examines biomarkers associated with biological stages of diseases like cardiovascular disease.
Discovery and Preclinical Validation of Salivary Transcriptomic and Proteomic Biomarkers for the Non-Invasive Detection of Breast Cancer
2010 · cited by 272
Demonstrates that salivary transcriptomic and proteomic signatures can serve as biomarkers for breast cancer detection.
Salivary markers of systemic disease: noninvasive diagnosis of disease and monitoring of general health.
2002 · cited by 239
Explores how clinicians use salivary analyses to diagnose systemic disease and monitor general health.
Salivary Exosomes: Emerging Roles in Systemic Disease
2018 · cited by 190
Highlights the emerging role of salivary exosomes as potential biomarkers of systemic diseases.