Evidence from clinical reviews and studies confirms that Roux-en-Y bariatric surgery alters gastrointestinal anatomy and promotes changes in gut hormone signaling—specifically increasing satiety hormones like GLP-1 and PYY and altering ghrelin—which help suppress hunger and food intake.
Multiple contemporary reviews and clinical studies confirm that bariatric surgeries, including Roux-en-Y gastric bypass, induce structural and physiological changes in the GI tract that lead to enhanced secretion of satiety-promoting gut hormones (such as GLP-1 and PYY) and altered ghrelin signaling, thereby suppressing appetite and hunger. None of the retrieved papers contradict this physiological mechanism.