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the claim
RNA polymerase predictably fails to transcribe repetitive sequences accurately
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
6 sources for · 0 against

Multiple studies demonstrate that RNA polymerases predictably undergo transcriptional slippage or inaccurate synthesis when encountering repetitive sequences and homopolymeric stretches.

Evidence for · 6
Transcriptional slippage in the positive-sense RNA virus family Potyviridae
2015 · cited by 198
Demonstrates that viral RNA polymerases predictably undergo transcriptional slippage when encountering conserved repetitive sequences like GAAAAAA.
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The analysis

The retrieved papers consistently report that RNA polymerases across various organisms and viruses predictably experience transcriptional slippage (indels) when transcribing repetitive sequences and homopolymeric runs. No papers refute this phenomenon; instead, they detail its mechanisms, predictability, and biological consequences. Therefore, the verdict is SUPPORTED.

More for · 5
Massively Systematic Transcript End Readout (MASTER): Transcription Start Site Selection, Transcriptional Slippage, and Transcript Yields
2015 · cited by 72
Shows via high-throughput sequencing that reiterative initiation and transcriptional slippage occur predictably from the majority of transcription start site region sequences.
Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses
2016 · cited by 46
Indicates that viral RNA-dependent RNA polymerases predictably slip at conserved homopolymeric motifs to produce alternative reading frame proteins.
Non-programmed transcriptional frameshifting is common and highly RNA polymerase type-dependent
2018 · cited by 10
Compares RNA polymerases and confirms that they predictably exhibit propensity for non-programmed transcriptional slippage at homopolymeric sequences in a sequence-dependent manner.
Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites
2018 · cited by 8
Finds that viral polymerases predictably slip at specific homopolymeric nucleotide runs during RNA synthesis.
Reconceptualizing transcriptional slippage in plant RNA viruses
2024 · cited by 6
Highlights that transcriptional slippage by viral replicases consistently occurs when transcribing specific repetitive motifs such as An stretches.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 8904 Aug 2026
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