Rheumatoid arthritis has a significant genetic heritability
the verdict
SUPPORTED
the evidence backs this
confidence 100/100
Rheumatoid arthritis is widely supported by genetic research and epidemiological reviews to possess significant heritability, driven by both HLA genes (such as the shared epitope) and various non-HLA susceptibility loci.
Evidence for · 4
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
2007 · cited by 9,680
Wellcome Trust Case Control Consortium (2007) identified specific disease susceptibility loci for rheumatoid arthritis through a genome-wide association study.
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More for · 3
Etiology and Risk Factors for Rheumatoid Arthritis: A State-of-the-Art Review
2021 · cited by 188
Biernacki et al. (2021) review host risk factors for rheumatoid arthritis, explicitly categorizing genetic factors as central contributors to disease susceptibility.
Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review.
2019 · cited by 175
Ahmad et al. (2019) report that the heritability of rheumatoid arthritis is estimated between 50% and 60%, with significant contributions from HLA and non-HLA genes.
Epidemiology and Risk Factors for Rheumatoid Arthritis Development
2023 · cited by 131
Viatte et al. (2023) highlight that rheumatoid arthritis pathogenesis is multifactorial, with genetic risk factors like the shared epitope playing a major role in disease occurrence.