Rheumatoid arthritis has a significant genetic heritability
Rheumatoid arthritis is widely supported by genetic research and epidemiological reviews to possess significant heritability, driven by both HLA genes (such as the shared epitope) and various non-HLA susceptibility loci.
The claim that rheumatoid arthritis has a significant genetic heritability is well-established in the literature. Papers such as Biernacki et al. (2021), Ahmad et al. (2019), and Viatte et al. (2023) directly support this by discussing the estimated heritability percentages and specific genetic risk factors (like HLA alleles and the shared epitope), while GWAS studies like the Wellcome Trust Case Control Consortium (2007) provide the underlying genomic evidence. There are no papers refuting the genetic contribution.
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Wellcome Trust Case Control Consortium (2007) identified specific disease susceptibility loci for rheumatoid arthritis through a genome-wide association study.
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Vasco C. Romão, João Eurico Fonseca. Etiology and Risk Factors for Rheumatoid Arthritis: A State-of-the-Art Review. 2021. https://doi.org/10.3389/fmed.2021.689698
Biernacki et al. (2021) review host risk factors for rheumatoid arthritis, explicitly categorizing genetic factors as central contributors to disease susceptibility.
Jafar Karami, S. Aslani, A. Jamshidi, M. Garshasbi, M. Mahmoudi. Genetic implications in the pathogenesis of rheumatoid arthritis; an updated review.. 2019. https://doi.org/10.1016/j.gene.2019.03.033
Ahmad et al. (2019) report that the heritability of rheumatoid arthritis is estimated between 50% and 60%, with significant contributions from HLA and non-HLA genes.
Aliki I. Venetsanopoulou, Yannis Alamanos, Paraskevi V. Voulgari, Alexandros A. Drosos. Epidemiology and Risk Factors for Rheumatoid Arthritis Development. 2023. https://doi.org/10.31138/mjr.301223.eaf
Viatte et al. (2023) highlight that rheumatoid arthritis pathogenesis is multifactorial, with genetic risk factors like the shared epitope playing a major role in disease occurrence.
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