Reference ranges for blood tests are determined using reliable statistical methods
the verdict
SUPPORTED
the evidence backs this
confidence 85/100
Reference ranges for clinical blood tests are systematically determined using established parametric, nonparametric, and regression-based statistical methods applied to well-defined reference populations.
Evidence for · 11
Regression-based reference limits: determination of sufficient sample size
1998 · cited by 42
This study demonstrates that regression-based statistical methods can reliably determine covariate-dependent reference limits when adequate sample sizes are used.
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More for · 10
Determination of sex-specific 99th percentile upper reference limits for a point of care high sensitivity cardiac troponin I assay
2021 · cited by 39
The 99th percentile upper reference limits for high-sensitivity cardiac troponin assays are established using established nonparametric statistical methods on well-filtered healthy cohorts.
Reference intervals for hematology test parameters from apparently healthy individuals in southwest Ethiopia
2018 · cited by 33
Statistical software and non-parametric tests like the Mann-Whitney U test are standardly applied to generate reliable population-specific hematology reference intervals.
Determination of high sensitive cardiac troponin I 99th percentile upper reference limits in a healthy Pakistani population
2020 · cited by 17
Non-parametric statistical methods are utilized to accurately determine upper reference limits for cardiac biomarkers in healthy populations.
Effect of sample size and the traditional parametric, nonparametric, and robust methods on the establishment of reference intervals: Evidence from real world data.
2021 · cited by 15
Standard parametric, nonparametric, and robust statistical methods are evaluated to establish consistent reference intervals based on sample size requirements.
Statistical methods used in the estimation of age-specific paediatric reference intervals for laboratory blood tests: a systematic review.
2020 · cited by 12
This systematic review catalogs the various robust statistical methods and curve-fitting approaches used to determine continuous age-specific reference intervals.
Parametric methods for estimating covariate-dependent reference limits
2004 · cited by 7
Generalized linear models and parametric normal distribution theory serve as reliable statistical options for estimating covariate-dependent reference limits when properly verified.
Determination of reference intervals of hemogram with advanced clinical parameters by indirect method on Sysmex XN-1000
2023 · cited by 4
Indirect methods utilizing non-parametric percentage estimation are successfully applied to calculate standard and advanced clinical parameter reference intervals.
Indirect Determination of Hematological Reference Intervals in Healthy Moroccan Adults Using Outpatient Data.
2024 · cited by 2
Nonparametric techniques combined with appropriate clinical selection criteria allow for the reliable indirect determination of hematological reference intervals.
Use of patient data in calculation of reference intervals for complete blood count parameters; how reliable?
2021 · cited by 1
Standard statistical methods successfully calculate reference intervals from large patient databases, yielding results comparable to those from healthy subject studies.
Verification of harmonized reference intervals in Croatia: is it time for a change?
2026 · cited by 0
Standard guidelines are used to verify and validate laboratory reference intervals across hematology, coagulation, and clinical chemistry.