PRP or MSC injections help treat spinal arthritis and disc problems
the verdict
SUPPORTED
the evidence backs this
confidence 87/100
Current clinical and preclinical evidence indicates that PRP and mesenchymal stem cell (MSC) injections can help manage spinal disc degeneration and associated pain by promoting tissue regeneration and reducing inflammation.
Evidence for · 12
Effects of the intradiscal implantation of stromal vascular fraction plus platelet rich plasma in patients with degenerative disc disease
2017 · cited by 81
Evaluated stromal vascular fraction and PRP intra-discally in patients with degenerative disc disease, finding significant pain and functional score improvements with a strong safety profile.
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More for · 11
A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration
2017 · cited by 44
Demonstrated that mesenchymal stem cells induce a strong recovery in intervertebral discal pathology and reduce degeneracy scores in an animal model.
A new strategy for intervertebral disc regeneration: The synergistic potential of mesenchymal stem cells and their extracellular vesicles with hydrogel scaffolds.
2024 · cited by 30
Reviewed how mesenchymal stem cells and extracellular vesicles offer promising regenerative potential for treating degenerating intervertebral discs.
Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?
2021 · cited by 23
Conducted a systematic review and meta-analysis indicating that intradiscal PRP injections show beneficial pain-relief effects in lumbar disc disease management.
A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration
2023 · cited by 23
Reviewed methods and mechanisms showing that mesenchymal stem cell therapy promotes extracellular matrix production and differentiation for intervertebral disc regeneration.
Systemic Review: Is an Intradiscal Injection of Platelet-Rich Plasma for Lumbar Disc Degeneration Effective?
2020 · cited by 19
Found that intradiscal PRP injections resulted in statistically significant pain reduction in patients with degenerative disc disease.
Bone Marrow-Derived Mesenchymal Stem Cells Augment Regeneration of Intervertebral Disc in a Reproducible and Validated Mouse Intervertebral Disc Degeneration Model
2021 · cited by 8
Demonstrated that bone marrow-derived mesenchymal stem cells promote disc height restoration and regeneration in a validated disc degeneration model.
Cryopreserved Mesenchymal Stem Cells Stimulate Regeneration in an Intervertebral Disc
2015 · cited by 5
Showed that cryopreserved mesenchymal stem cells stimulate structural restoration and tissue repair in degenerated intervertebral discs.
Role of Platelet-Rich Plasma (PRP) in the Management of Stage III and IV Degenerative Disc Disease
2025 · cited by 4
Summarized that PRP therapy promotes tissue regeneration, modulates inflammation, and improves functionality in degenerative disc disease.
How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration
2023 · cited by 4
Highlighted that mesenchymal stem cells help treat disc degeneration by differentiating into nucleus pulposus cells and promoting extracellular matrix repair.
Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells
2025 · cited by 4
Discussed how mesenchymal stem cell-based therapies demonstrate potential for intervertebral disc regeneration and anti-inflammation.
Intradiscal Leukocyte Rich Platelet Rich Plasma for Degenerative Disc Disease.
2022 · cited by 3
Recognized degenerative disc disease as a primary cause of chronic low back pain where improved biological solutions like PRP are actively being investigated.