Proton pump inhibitors shut down proton pumps in all cells across the body

the verdict

REFUTED

the evidence says no

Recorded sources

0 sources for · 4 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Proton pump inhibitors do not affect proton pumps across all cells in the body; rather, they specifically target the hydrogen-potassium ATPase pumps located within gastric parietal cells to suppress stomach acid secretion.

The analysis

The claim states that PPIs shut down proton pumps in all cells across the body, which is physiologically incorrect. PPIs are specifically targeted prodrugs that accumulate in gastric parietal cells and inhibit gastric H+, K+-ATPase. The retrieved papers consistently describe PPIs as agents acting selectively on parietal cells for gastric acid-related disorders, directly refuting the idea of systemic or universal cellular proton pump inhibition.

Evidence against · 4

25 Years of Proton Pump Inhibitors: A Comprehensive Review

Recorded source metadata

Daniel S. Strand, Daejin Kim, David A. Peura. 25 Years of Proton Pump Inhibitors: A Comprehensive Review. 2016. https://doi.org/10.5009/gnl15502

Paper 0 notes that PPIs specifically inhibit active parietal cell acid secretion rather than proton pumps across all cells in the body.

Source citation format

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More against · 3

Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors

Recorded source metadata

Jai Moo Shin, Nayoung Kim. Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors. 2013. https://doi.org/10.5056/jnm.2013.19.1.25

Paper 2 discusses how PPIs specifically target and bind covalently to the gastric H+, K+-ATPase in parietal cells.

Source citation format

The Physiology of the Gastric Parietal Cell

Recorded source metadata

Amy C. Engevik, Izumi Kaji, James R. Goldenring. The Physiology of the Gastric Parietal Cell. 2019. https://doi.org/10.1152/physrev.00016.2019

Paper 3 describes parietal cells as the unique cells responsible for gastric acid secretion via the H+-K+-ATPase enzyme.

Source citation format

[Current status and prospects of using potassium-competitive acid blockers in gastroenterology].

Recorded source metadata

I. Maev, D. N. Andreev, A. V. Zaborovsky, A. K. Fomenko. [Current status and prospects of using potassium-competitive acid blockers in gastroenterology].. 2025. https://doi.org/10.26442/00403660.2025.08.203381

Paper 6 explains that PPIs and P-CABs act specifically on hydrogen potassium adenosine triphosphatase in the parietal cells of the stomach.

Source citation format

The paper trail · every fact has a biography

first checked02 Aug 2026

judged → REFUTED · 1802 Aug 2026

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