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the claim

Positive and negative supercoiling represent distinct states of DNA coiling

the verdict

SUPPORTED

the evidence backs this

confidence 75/100

Positive and negative supercoiling represent distinct states of DNA coiling with unique topological properties, genomic distributions, and biological functions.

Evidence for · 2

Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling

2026 · cited by 0

Paper 2 notes that while negative supercoiling has been extensively studied, positive supercoiling has distinct biological roles and accumulation sites, establishing them as separate topological states.

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More for · 1

Differential roles of positive and negative supercoiling in organizing the <i>E. coli</i> genome

2022 · cited by 0

Paper 4 shows that positive and negative supercoiling have differential roles in organizing the genome and distinct effects on spatial contact frequencies.

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first checked01 Aug 2026

judged → SUPPORTED · 7501 Aug 2026

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