Positive and negative supercoiling represent distinct states of DNA coiling

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Positive and negative supercoiling represent distinct states of DNA coiling with unique topological properties, genomic distributions, and biological functions.

The analysis

The claim is a well-established molecular biology concept supported by recent literature differentiating the roles and locations of positive and negative DNA supercoiling.

Evidence for · 2

Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling

Recorded source metadata

Ashish Kumar Singh, Luis Altamirano-Pacheco, Lieng Taing, Agnès Dubois, Pablo Navarro. Topological Regulation of the Mammalian Genome by Positive DNA Supercoiling. 2026. https://doi.org/10.64898/2026.03.10.710740

Paper 2 notes that while negative supercoiling has been extensively studied, positive supercoiling has distinct biological roles and accumulation sites, establishing them as separate topological states.

Source citation format

See more details

More for · 1

Differential roles of positive and negative supercoiling in organizing the <i>E. coli</i> genome

Recorded source metadata

Ziqi Fu, Monica S. Guo, Weiqiang Zhou, Jie Xiao. Differential roles of positive and negative supercoiling in organizing the <i>E. coli</i> genome. 2022. https://doi.org/10.1101/2022.12.30.522362

Paper 4 shows that positive and negative supercoiling have differential roles in organizing the genome and distinct effects on spatial contact frequencies.

Source citation format

The paper trail · every fact has a biography

first checked01 Aug 2026

judged → SUPPORTED · 7501 Aug 2026

More receipts

Is it true that Phonological evolution involves regular processes of phoneme elision, vowel nasalization, and tonogenesis?Is it true that Hemangiomas are treatable with medication?Is it true that Research identifies forms of intelligence that diverge from standard IQ measures?

Random receipt →The Trust Wiki →

Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.

Check your own claim

Challenge the receipt

I have a source that contradicts this verdict I have a source that supports it No source: request a receipt review Requests are recorded for review. This does not start an automatic check or guarantee a response time.

trust me, bro: win the argument, pass the class, survive peer review.

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work · Dispute this receipt