Pfizer and Moderna vaccine effectiveness against Omicron becomes negative after three months.
the verdict
REFUTED
the evidence says no
confidence 11/100
Evidence shows that while vaccine effectiveness against the Omicron variant wanes over time, it decreases to lower positive levels rather than becoming negative after three months.
Evidence against · 3
Coronavirus Disease 19 (COVID-19) Vaccine Effectiveness Against Symptomatic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection During Delta-Dominant and Omicron-Dominant Periods in Japan: A Multicenter Prospective Case-control Study (Factors Associated with SARS-CoV-2 Infection a
2022 · cited by 63
Paper [1] found that vaccine effectiveness against Omicron remained positive (ranging from 49% to 56% depending on the time interval) even at 6 months or more after the second dose.
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More against · 2
Reported effectiveness of COVID-19 monovalent booster vaccines and hybrid immunity against mild and severe Omicron disease in adults: A systematic review and meta-regression analysis
2024 · cited by 13
Paper [4] demonstrated in a meta-regression analysis that while vaccine effectiveness waned over time against the Omicron variant, it remained positive rather than dropping below zero.
Waning Effectiveness of the Third Dose of the BNT162b2 mRNA COVID-19 Vaccine
2022 · cited by 7
Paper [6] specifically examined the BNT162b2 booster dose against Omicron at three months post-vaccination and reported a positive relative protection value of 16.5% rather than a negative effectiveness.