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Pectus excavatum increases the risk of cardiovascular disease
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INSUFFICIENT LEANING
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2 sources for · 0 against

Available medical literature indicates that pectus excavatum can impair cardiac function by compressing the heart, but evidence directly establishing an increased risk of long-term cardiovascular disease is lacking.

Evidence for · 2
2016 · cited by 31
Patients with pectus excavatum (PE) often describe improvements in exercise stamina following corrective surgery. Studies have investigated the surgical effect on physiological parameters; still, no consensus has yet been reached. Therefore, the aim of this literature review was to describe the cardiac outcome after surgical correction, both at rest and during exercise. In February 2016, a detailed search of the databases PubMed, Medline, and EMBASE was performed. We assessed clinical studies that described cardiac outcomes both before and after surgical correction of PE. We only included studies reporting either pre-defined echocardiographic or exercise test parameters. No exclusion criteria or statistical analyses were applied. Twenty-one full-text articles, published between 1972 and 2016, were selected, with cohort-ranges of 3-168 patients, mean age-ranges of 5-33 years, and mean follow-up-ranges from immediately to 4 years after surgery. Twelve studies described resting cardiac parameters. Four studies measured cardiac output, where one described 36% immediate increase after surgery, one reported 15% increase after Nuss-bar removal and two found no difference. Three studies demonstrated improvement in mean stroke volume ranges of 22-34% and two studies found no difference. Fifteen studies investigated exercise capacity, with 11 considering peak O<sub>2</sub> pr. kg, where five studies demonstrated improvements with the mean ranging from 8% to 15% after surgery, five studies demonstrated no difference, and one saw a decrease of 19% 3 months after Nuss-bar implantation. A measurable increase in exercise capacity exists following surgery, which may be caused by multiple factors. This may be owed to the relief of compressed cardiac chambers with the increased anterior-posterior thoracic dimensions, which could facilitate an improved filling of the heart. With these results, the positive physiological impact of the surgery is emphasized and the potential gain in car (15) evaluated the maximum short axis of the right ventricle shortly after the turning of the Nuss-bar and found significant increases both in the transverse distance 487Annals of cardiothoracic surgery, Vol 5, No 5 September 2016 © AME Publishing Company. Ann Cardiothorac Surg 2016;5(5):485-492 | https://dx.doi.org/10.21037/acs.2016.09.03 Table 1 Characteristics of studies reporting the impact of surgical correction of pectus excavatum on cardiac function Authors Type of surgery Patient No. The main consensuses are increased right ventricular volumes and, more importantly, increased exercise capacity as an indirect measure of cardiac function. Cardiac function at rest Generally the ejection fraction does not appear to increase following surgery. Only one study (18) demonstrated an increase in left ventricular ejection fraction. Although statistically significant, standard Bawazir OA, Montgomery M, Harder J, et al. Midterm evaluation of cardiopulmonary effects of closed repair for pectus excavatum. J Pediatr Surg 2005;40:863-7. 12. Tang M, Nielsen HH, Lesbo M, et al. Improved cardiopulmonary exercise function after modified Nuss operation for pectus excavatum. Eur J Cardiothorac Surg 2012;41:1063-7. 13. Wurtz A, Rousse N, Benhamed L, et al. Simplified open repair for anterior chest wall deformities. Analysis of results in 205 patients. Orthop Traumatol Surg Res 2012;98:319-26. 14. Kowalewski J, Brocki M, Dryjanski T, et al. Pectus excavatum: increase of right ventricular systolic, diastolic, and stroke volumes after surgical repair. J Thorac Cardiovasc Surg 1999;118:87-92; discussion 92-3. 15. Huang PM, Liu CM, Cheng YJ, et al. Evaluation of intraoperative cardiovascular responses to closed repair for pectus excavatum. Thorac Cardiovasc Surg 2008;56:353-8. 16. Gürkan U, Aydemir B, Aksoy S, et al. Echocardiographic assessment of right ventricular function before and after surgery in patients with pectus excavatum and right ventricular compression. Thorac Cardiovasc Surg 2014;62:231-5. 17. Neviere R, Montaigne D, Benhamed L, et al. Cardiopulmonary response following surgical repair of pectus excavatum in adult patients. Eur J Cardiothorac Surg 2011;40:e77-82. 18. Krueger T, Chassot PG, Christodoulou M, et al. Coln E, Carrasco J, Coln D. Demonstrating relief of cardiac compression with the Nuss minimally invasive repair for pectus excavatum. J Pediatr Surg 2006;41:683-6; discussion 683-6. 27. Udholm S, Maagaard M, Pilegaard H, et al. Cardiac function in adults following minimally invasive repair of pectus excavatum. Interact Cardiovasc Thorac Surg 2016;22:525-9. 28. Neviere R, Benhamed L, Duva Pentiah A, et al. Pectus excavatum repair improves respiratory pump efficacy and cardiovascular function at exercise. J Thorac Cardiovasc Surg 2013;145:605-6. 29. Castellani C, Windhaber J, Schober PH, et al. Exercise performance testing in patients with pectus excavatum before and after Nuss procedure. Pediatr Surg Int 2010;26:659-63. 30. Borowitz D, Cerny F, Zallen G, et al. Pulmonary function and exercise response in patients with pectus excavatum after Nuss repair. J Pediatr Surg 2003;38:544-7. 31. Morshuis WJ, Folgering HT, Barentsz JO, et al. Exercise cardiorespiratory function before and one year after operation for pectus excavatum. J Thorac Cardiovasc Surg 1994;107:1403-9. 32. Cahill JL, Lees GM, Robertson HT. A summary of preoperative and postoperative cardiorespiratory performance in patients undergoing pectus excavatum and carinatum repair. J Pediatr Surg 1984;19:430-3. 33. Haller JA Jr, Loughlin GM. Cardiorespiratory function is significantly improved following corrective surgery for severe pectus excavatum. Proposed treatment guidelines. J Cardiovasc Surg (Torino) 2000;41:125-30. Cite this article as: Maagaard M, Heiberg J. Improved cardiac function and exercise capacity following correction of pectus excavatum: a review of current literature. Ann Cardiothorac Surg 2016;5(5):485-492. doi: 10.21037/acs.2016.09.03
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Pectus excavatum is a structural deformity of the anterior thoracic wall in which the sternum and rib cage are shaped abnormally. This produces a caved-in Pectus excavatum is a structural deformity of the anterior thoracic wall in which the sternum and rib cage are shaped abnormally. This produces a caved-in or sunken appearance of the chest. It can either be present at birth or develop after puberty. Pectus excavatum can impair cardiac and respiratory function and cause pain in the chest and back. People with the condition may experience severe neg Pectus excavatum is a structural deformity of the anterior thoracic wall in which the sternum and rib cage are shaped abnormally. This produces a caved-in or sunken appearance of the chest. It can either be present at birth or develop after puberty. Pectus excavatum can impair cardiac and respiratory function and cause pain in the chest and back. People with the condition may experience severe negative psychosocial effects and avoid activities that expose the chest. Chest… There has been controversy as to the best surgical approach for the correction of pectus excavatum. It is important for the surgeon to select the appropriate operative approach based on each individual's characteristics. Surgical correction has been shown to repair any functional symptoms that may occur in the condition, such as respiratory problems or heart murmurs, provided that permanent damage has not already arisen from an extremely severe case. Surgical correction of the pectus excavatum has been shown to significantly improve cardiovascular function, but so far there is inconclusive evidence as to whether it might also improve pulmonary function. One of the most popular techniques for repair of pectus excavatum today is the minimally invasive operation, also known as MIRPE or Nuss technique, with a system of bars made of metal. Pectus excavatum is a structural deformity of the anterior thoracic wall in which the sternum and rib cage are shaped abnormally. This produces a caved-in or sunken appearance of the chest. It can either be present at birth or develop after puberty. Pectus excavatum can impair cardiac and respiratory function and cause pain in the chest and back. People with the condition may experience severe negative psychosocial effects and avoid activities that expose the chest. Pectus excavatum is initially suspected from visual examination of the anterior chest. Auscultation of the chest can reveal displaced heartbeat and valve prolapse. There can be a heart murmur occurring during systole caused by proximity between the sternum and the pulmonary artery. Lung sounds are usually clear yet diminished due to decreased base lung capacity. Many scales have been developed to determine the degree of deformity in the chest wall. Most of these are variants on the distance between the sternum and the spine. One such index is the Backer ratio which grades the severity of deformity based on the ratio between the diameter of the vertebral body nearest to xiphosternal junction and the distance between the xiphosternal junction and the nearest vertebral body. More recently the Haller index has been used based on CT scan measurements. An index over 3.25 is often defined as severe. The Haller index is the ratio between the horizontal distance of the inside of the ribcage and the shortest distance between the vertebrae and sternum. Chest x-rays are also useful in the diagnosis. The chest x-ray in pectus excavatum can show an opacity in the right lung area that can be mistaken for an infiltrate (such as that seen with pneumonia). Some studies also suggest that the Haller index can be calculated based on chest x-ray as opposed to CT scanning in individuals who have no limitation in their function. Pectus excavatum is differentiated from other disorders by a series of elimination of signs and symptoms. Pectus carinatum is excluded by the simple observation of a collapsing of the sternum rather than a protrusion. Kyphoscoliosis is excluded by diagnostic imaging of the spine, wherein pectus excavatum, the spine usually appears normal in structure. There has been controversy as to the best surgical approach for the correction of pectus excavatum. It is important for the surgeon to select the appropriate operative approach based on each individual's characteristics. Surgical correction has been shown to repair any functional symptoms that may occur in the condition, such as respiratory problems or heart murmurs, provided that permanent damage has not already arisen from an extremely severe case. Surgical correction of the pectus excavatum has been shown to significantly improve cardiovascular function, but so far there is inconclusive evidence as to whether it might also improve pulmonary function. One of the most popular techniques for repair of pectus excavatum today is the minimally invasive operation, also known as MIRPE or Nuss technique, with a system of bars made of metal. The Ravitch technique is an invasive surgery that was introduced in 1949 and developed in the 1950s. It involves creating an incision along the chest through which the cartilage is removed and the sternum detached. A small bar is inserted underneath the sternum to hold it up in the desired position. The bar is left implanted until the cartilage grows back, typically about six months. The bar is subsequently removed in a simple outpatient procedure; this technique is thus a two-stage procedure. The Ravitch technique is not widely practiced because it is so invasive. It is more often used in older individuals, where the sternum has calcified when the deformity is asymmetrical, or when the less invasive Nuss procedure has proven unsuccessful. The Ravitch procedure may be indicated in specific situations. For instance, it can be employed to address complex asymmetry, where the pectus excavatum exhibits a more pronounced depression on one side of the chest compared to the other. Additionally, the
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  1. Improved cardiac function and exercise capacity following correction of pectus excavatum: a review of current literature.peer-reviewedno side taken
  2. Pectus excavatumreferenceno side taken
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