Background: Patients with diabetes mellitus (DM) are at higher risk for adverse events after MI, including death and recurrent ischemia. As such, we sought to develop prediction models to identify DM patients at highest risk for these outcomes. Methods: We examined 3 adverse outcomes (3-year mortality, 1-year angina, 1-year MACE [mortality, MI, stroke, urgent revascularization]) among patients with DM discharged alive after MI from 24 US hospitals. Using Harrell’s backward selection, we developed hierarchical multivariable models with a parsimonious set of covariates for each outcome. The mortality and angina models were validated in a separate 19-site US MI registry. Results: Among 1626 DM patients, event rates were 19% for 3-year mortality, 11% for 1-year MACE, and 27% for 1-year angina. The models had good discrimination, with c-indices of 0.80, 0.72, and 0.73, respectively, and excellent calibration. The strongest predictors (in terms of F-value) were age, hemoglobin, and creatinine for mortality; depression, hemoglobin, and history of heart failure for MACE; and angina prior to MI, age, and prior CABG for angina (Table). The observed rates of outcomes in the lowest to highest decile of predicted risk ranged broadly for all 3 outcomes, with ranges of 1-58% for mortality, 1-38% for MACE, and 8-62% for angina. The mortality and angina models performed well in the validation cohort, although they tended to over-predict mortality at higher levels of risk and under-predict ang

In patients with unstable coronary artery disease, this study evaluated the degree of inflammation and coagulation activity, relations to myocardial cell damage, prognosis, and influences of randomisation to 72 h infusion with three different doses of inogatran, a direct thrombin inhibitor (n=904), or unfractionated heparin (n=305). Anticoagulant treatment effects were evaluated with aPT time. In inogatran treated patients with aPT times ≥ 44 s (median), the 7-days event rate - death, myocardial infarction or refractory angina – was 11.6 %, compared to 6.6 % with aPT times Markers of inflammat

now well established that patients with unstable angina have a high incidence of complex lesions … stratification As we have seen, patients with unstable angina have a variable prognosis and it … troponin I levels to predict the risk of mortality in patients with acute coronary syndromes, N