Patient body weight determines the proper dosage for specific pharmacological treatments
Multiple clinical and pharmacological studies demonstrate that patient body weight is a primary factor in determining proper drug dosages and optimizing therapeutic efficacy across diverse treatments.
The retrieved literature consistently shows that body weight (or its derivatives like adjusted body weight or body surface area) is a fundamental covariate utilized to determine appropriate pharmacological dosing, handle pharmacokinetic variability, and avoid toxicity across numerous drug classes and patient populations. No papers refute the basic premise that body weight guides proper dosing.
C. Hebbes, J. P. Thompson. Pharmacokinetics of anaesthetic drugs at extremes of body weight.. 2018. https://doi.org/10.1016/J.BJAE.2018.09.001
Prof Leic et al. (2018) note that total body weight or adjusted body weight guides proper dosing modifications, particularly for extreme weights.
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Ashley N Fox, Winter J Smith, Katherine E. Kupiec, S. Harding, B. Resman-Targoff, Stephen B. Neely, Bryan P. White, R. Owens. Daptomycin dosing in obese patients: analysis of the use of adjusted body weight versus actual body weight. 2019. https://doi.org/10.1177/2049936118820230
Daptomycin dosing regimens in clinical practice are evaluated based on actual versus adjusted body weight strategies in obese patient cohorts.
P. Pokorná, M. Šíma, O. Černá, K. Allegaert, D. Tibboel, O. Slanař. Actual body weight-based vancomycin dosing in neonates. 2019. https://doi.org/10.1080/1120009X.2019.1599574
Vancomycin pharmacokinetics in neonates are primarily driven by actual body weight, enabling practical weight-based dosing algorithms.
Zufei Zhang, Daping Zhang, Wenchuan Guo, Keenan Fenton, Sujata Narayanan, Shweta Jain, Joy X. Jiang, S. Castellino, Kara M. Kelly, Peter D. Cole, Frank G. Keller, Amit Garg, Y. Chia. Exposure–Response and Subgroup Analyses to Support Body Weight–Based Dosing of Brentuximab Vedotin in Children and Young Adults with Newly Diagnosed High-risk Classical Hodgkin Lymphoma. 2024. https://doi.org/10.1158/1078-0432.CCR-23-3655
Brentuximab vedotin dosage in children and young adults is established via body weight-based parameters (mg/kg).
Lava SAG, Di Deo A, D'Agate S, Della Pasqua O. Empagliflozin in paediatric heart failure: model-based optimisation of a pharmacokinetic bridging study.. 2025. https://doi.org/10.3389/fmed.2025.1522131
Empagliflozin disposition parameters scale allometrically with body weight to establish appropriate pediatric dosing guidelines.
Peng Zou. First-in-patient dose prediction for adeno-associated virus-mediated hemophilia gene therapy using allometric scaling. 2022. https://doi.org/10.1101/2022.07.05.498837
Body weight-based dose conversion approaches are widely utilized for first-in-patient dose predictions in gene therapy.
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