Patient body weight determines the proper dosage for specific pharmacological treatments
the verdict
SUPPORTED
the evidence backs this
confidence 84/100
Multiple clinical and pharmacological studies demonstrate that patient body weight is a primary factor in determining proper drug dosages and optimizing therapeutic efficacy across diverse treatments.
Evidence for · 6
Pharmacokinetics of anaesthetic drugs at extremes of body weight.
2018 · cited by 33
Prof Leic et al. (2018) note that total body weight or adjusted body weight guides proper dosing modifications, particularly for extreme weights.
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More for · 5
Daptomycin dosing in obese patients: analysis of the use of adjusted body weight versus actual body weight
2019 · cited by 27
Daptomycin dosing regimens in clinical practice are evaluated based on actual versus adjusted body weight strategies in obese patient cohorts.
Actual body weight-based vancomycin dosing in neonates
2019 · cited by 7
Vancomycin pharmacokinetics in neonates are primarily driven by actual body weight, enabling practical weight-based dosing algorithms.
Exposure–Response and Subgroup Analyses to Support Body Weight–Based Dosing of Brentuximab Vedotin in Children and Young Adults with Newly Diagnosed High-risk Classical Hodgkin Lymphoma
2024 · cited by 4
Brentuximab vedotin dosage in children and young adults is established via body weight-based parameters (mg/kg).
Empagliflozin in paediatric heart failure: model-based optimisation of a pharmacokinetic bridging study.
2025 · cited by 1
Empagliflozin disposition parameters scale allometrically with body weight to establish appropriate pediatric dosing guidelines.
First-in-patient dose prediction for adeno-associated virus-mediated hemophilia gene therapy using allometric scaling
2022 · cited by 1
Body weight-based dose conversion approaches are widely utilized for first-in-patient dose predictions in gene therapy.