Oxygen deprivation alters neural firing rates and induces synaptic failure
the verdict
SUPPORTED
the evidence backs this
confidence 88/100
Oxygen deprivation disrupts normal neural function, leading to altered firing patterns and synaptic failure.
Evidence for · 2
Intracellular Zn<sup>2+</sup>Accumulation Contributes to Synaptic Failure, Mitochondrial Depolarization, and Cell Death in an Acute Slice Oxygen–Glucose Deprivation Model of Ischemia
2009 · cited by 148
This study demonstrates that oxygen-glucose deprivation leads to mitochondrial dysfunction and the cessation of synaptic transmission (synaptic failure) in hippocampal neurons.
See more details
More for · 1
Geometrically-engineered human motor assembloids-on-a-chip for neuromuscular interaction readout and hypoxia-driven disease modeling.
2025 · cited by 1
This study shows that oxygen deprivation causes structural anomalies, muscle remodeling, and functional abnormalities in neuromuscular networks.