Over-healing of a wound can prevent complete tissue repair
the verdict
SUPPORTED
the evidence backs this
confidence 90/100
Over-healing and excessive fibrosis (such as hypertrophic scarring and pathological matrix deposition) disrupt normal tissue architecture and can prevent functional tissue repair.
Evidence for · 5
Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring
2008 · cited by 257
Demonstrates that blocking inflammation-associated osteopontin reduces excessive scarring and accelerates normal tissue repair.
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More for · 4
TGF‐β–induced fibrosis and SMAD signaling: oligo decoys as natural therapeutics for inhibition of tissue fibrosis and scarring
2007 · cited by 128
Indicates that persistent TGF-beta activity drives excessive fibrosis, leading to impaired tissue structure and organ malfunction.
Exosomes in Hypertrophic Scars and Keloids: Mechanisms and Therapeutic Potentials-A Narrative Review.
2026 · cited by 1
Notes that pathological scars arise from dysregulated wound healing marked by excessive extracellular matrix deposition and abnormal fibroblast activation.
4E-BP1 acts as a molecular rheostat balancing regenerative healing and fibrotic scarring.
2026 · cited by 0
Shows that the mTORC1 effector 4E-BP1 balances reparative efficiency and fibrotic remodeling, where unchecked signaling promotes excessive collagen deposition.
[The mechanism and research progress of thymic stromal lymphopoietin in chronic wound fibrosis].
2026 · cited by 0
Explains that while moderate fibrosis protects a wound, excessive fibrosis leads to pathological scarring that impedes complete healing.