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the claim
Outer hair cells actively amplify the traveling wave in the cochlea.
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
8 sources for · 0 against

Multiple studies and reviews confirm that outer hair cells utilize active electromotility (driven by the motor protein prestin) to amplify the fluid traveling wave along the cochlea, enhancing mammalian hearing sensitivity and frequency selectivity.

Evidence for · 8
Cochlear Amplification in the Short-Wave Region by Outer Hair Cells changing Organ-of-Corti area to Amplify the Fluid Traveling Wave
2022 · cited by 20
Discusses how outer-hair-cell motility produces traveling-wave amplification in the cochlea.
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The analysis

The retrieved papers consistently support the claim that outer hair cells actively amplify the traveling wave in the cochlea, detailing the biophysical and molecular mechanisms (such as prestin electromotility) responsible for this cochlear amplification.

More for · 7
Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification
2023 · cited by 15
Notes that prestin electromotility in outer hair cells powers cochlear amplification.
Elevator-like movements of prestin mediate outer hair cell electromotility
2023 · cited by 13
Identifies elevator-like movements of prestin in outer hair cells as mediating cochlear amplification.
A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification
2022 · cited by 10
Demonstrates that outer hair cell potentials drive high-frequency cochlear amplification.
An outer hair cell-powered global hydromechanical mechanism for cochlear amplification
2021 · cited by 8
Examines the outer hair cell-powered mechanism that drives cochlear amplification.
MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss
2024 · cited by 7
Links outer hair cell electromotility via prestin function directly to the regulation of cochlear amplification.
Amplification through local critical behavior in the mammalian cochlea.
2025 · cited by 6
Attributes mammalian hearing sensitivity to an active process powered by outer hair cells that energizes the traveling wave.
Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility
2023 · cited by 6
Connects prestin's voltage-dependent conformational changes to outer hair cell electromotility and cochlear amplification.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. Interfacing with the Brain: How Nanotechnology Can Contribute.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Cochlear Amplification in the Short-Wave Region by Outer Hair Cells changing Organ-of-Corti area to Amplify the Fluid Traveling Wavepeer-reviewedsupports
  3. Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplificationpeer-reviewedsupports
  4. A resonance approach to cochlear mechanics.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Elevator-like movements of prestin mediate outer hair cell electromotilitypeer-reviewedsupports
  6. A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplificationpeer-reviewedsupports
  7. An outer hair cell-powered global hydromechanical mechanism for cochlear amplificationpeer-reviewedsupports
  8. MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing losspeer-reviewedsupports
  9. Amplification through local critical behavior in the mammalian cochlea.peer-reviewedsupports
  10. Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotilitypeer-reviewedsupports
  11. Conversations in Cochlear Implantation: The Inner Ear Therapy of Today.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Hair Cells in the Cochlea Must Tune Resonant Modes to the Edge of Instability without Destabilizing Collective Modes.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → SUPPORTED · 8306 Aug 2026
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