Organelle membranes differ significantly in their lipid and protein composition
Multiple studies demonstrate that cellular organelles possess distinct and characteristic lipid and protein compositions that dictate their unique functional properties.
The retrieved papers consistently support the well-established biological fact that different organelles (such as the ER, mitochondria, Golgi, and lysosomes) maintain distinct lipid and protein profiles, which contribute to their specific membrane properties and functions.
Shane Minogue, Mark G. Waugh. Lipid rafts, microdomain heterogeneity and inter‐organelle contacts: Impacts on membrane preparation for proteomic studies. 2012. https://doi.org/10.1111/boc.201200020
Discusses lateral heterogeneities and distinct intra-membrane lipid and protein concentrations across subcellular compartments.
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V. Dumrongprechachan, G. Soto, M.L. MacDonald, Y. Kozorovitskiy. Cell type and subcellular compartment specific APEX2 proximity labeling proteomics in the mouse brain. 2021. https://doi.org/10.1101/2021.04.08.439091
Highlights that subcellular compartments contain divergent proteomes essential for their specific functions.
Adrian M. Wong, Itay Budin. Organelle-targeted Laurdans measure heterogeneity in subcellular membranes and their responses to saturated lipid stress. 2024. https://doi.org/10.1101/2024.04.16.589828
Demonstrates that cell organelles feature characteristic lipid compositions that lead to differences in membrane properties and fluidity.
Adrian M Wong, Itay Budin. Organelle-Targeted Laurdans Measure Heterogeneity in Subcellular Membranes and Their Responses to Saturated Lipid Stress.. 2024. https://doi.org/10.1021/acschembio.4c00249
Confirms that individual cellular organelles possess distinct lipid compositions and membrane packing characteristics.
Lipika Mirdha, Tanusree Sengupta, Hirak Chakraborty. Lipid composition dependent binding of apolipoprotein E signal peptide: Importance of membrane cholesterol in protein trafficking.. 2022. https://doi.org/10.1016/j.bpc.2022.106907
Notes that subcellular organelles contain differential amounts of lipids such as cholesterol, affecting protein targeting.
Beyenech Binotti, Momchil Ninov, Andreia P Cepeda, Marcelo Ganzella, Ulf Matti, Dietmar Riedel, Henning Urlaub, Sivakumar Sambandan, Reinhard Jahn. ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals.. 2024. https://doi.org/10.1080/15548627.2023.2274204
Shows that distinct vesicle populations and organelles exhibit notable heterogeneity in their membrane composition.
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