Organelle membranes differ significantly in their lipid and protein composition
the verdict
SUPPORTED
the evidence backs this
confidence 82/100
Multiple studies demonstrate that cellular organelles possess distinct and characteristic lipid and protein compositions that dictate their unique functional properties.
Evidence for · 6
Lipid rafts, microdomain heterogeneity and inter‐organelle contacts: Impacts on membrane preparation for proteomic studies
2012 · cited by 10
Discusses lateral heterogeneities and distinct intra-membrane lipid and protein concentrations across subcellular compartments.
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More for · 5
Cell type and subcellular compartment specific APEX2 proximity labeling proteomics in the mouse brain
2021 · cited by 7
Highlights that subcellular compartments contain divergent proteomes essential for their specific functions.
Organelle-targeted Laurdans measure heterogeneity in subcellular membranes and their responses to saturated lipid stress
2024 · cited by 1
Demonstrates that cell organelles feature characteristic lipid compositions that lead to differences in membrane properties and fluidity.
Organelle-Targeted Laurdans Measure Heterogeneity in Subcellular Membranes and Their Responses to Saturated Lipid Stress.
2024 · cited by 0
Confirms that individual cellular organelles possess distinct lipid compositions and membrane packing characteristics.
Lipid composition dependent binding of apolipoprotein E signal peptide: Importance of membrane cholesterol in protein trafficking.
2022 · cited by 0
Notes that subcellular organelles contain differential amounts of lipids such as cholesterol, affecting protein targeting.
ATG9 resides on a unique population of small vesicles in presynaptic nerve terminals.
2024 · cited by 0
Shows that distinct vesicle populations and organelles exhibit notable heterogeneity in their membrane composition.