Oral sex is a leading cause of throat cancer
High-risk human papillomavirus (HPV), frequently transmitted via oral sex, is a major and rapidly growing cause of oropharyngeal (throat) cancer, replacing tobacco and alcohol as the leading risk factor in many developed regions.
The retrieved papers consistently establish that high-risk HPV is a leading cause of oropharyngeal cancer and that oral sex is the primary transmission route for these oncogenic infections. Multiple reviews and meta-analyses support this epidemiological link, and no papers dispute the causal connection.
M. Tambas, M. Altun, D. Tural. Human Papillomavirus in Head and Neck Cancer. 2016. https://doi.org/10.5772/63014
This paper notes that human papillomavirus (HPV) infection causes a rapidly spreading subtype of head and neck cancers, with patients exhibiting higher numbers of oral sex partners.
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Jonas Wolf, Lucas Felipe Kist, Samanta Brangel Pereira, Marilze Alves Quessada, Helena Petek, Arthur Pille, Juçara Gasparetto Maccari, Mohamed Parrini Mutlaq, Luiz Antonio Nasi. Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics.. 2024. https://doi.org/10.1002/rmv.2537
This source states that high-risk HPV types are strongly associated with oropharyngeal cancers and that HPV is primarily transmitted through sexual contact, including oral sex.
M Taberna, M Mena, M A Pavón, L Alemany, M L Gillison, R Mesía. Human papillomavirus-related oropharyngeal cancer.. 2017. https://doi.org/10.1093/annonc/mdx304
This review highlights that high-risk HPV is the principal cause of increasing oropharyngeal squamous cell carcinoma and that the majority of oral HPV infections are acquired through oral sex.
Aikaterini Tsentemeidou, Georgios Fyrmpas, Marios Stavrakas, Konstantinos Vlachtsis, Elena Sotiriou, Alexandros Poutoglidis, Nikolaos Tsetsos. Human Papillomavirus Vaccine to End Oropharyngeal Cancer. A Systematic Review and Meta-Analysis.. 2021. https://doi.org/10.1097/OLQ.0000000000001405
This meta-analysis reports that oral HPV16 infection causes the vast majority of HPV-related oropharyngeal cancers and is primarily linked to oral sex.
Nam P Nguyen, Ly M Nguyen, Sroka Thomas, Bevan Hong-Ly, Alexander Chi, Paul Vos, Ulf Karlsson, Vincent Vinh-Hung. Oral sex and oropharyngeal cancer: The role of the primary care physicians.. 2016. https://doi.org/10.1097/MD.0000000000004228
This systematic review discusses how oral sex practices are associated with HPV16 infection and the subsequent development of oropharyngeal cancer.
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