Opening the chest cavity promotes the spread or growth of disease
the verdict
OVERSTATED
true in a weaker form than the claim states
confidence 0/100
While surgical trauma can induce microenvironmental changes that theoretically favor metastasis, extensive clinical trial evidence demonstrates that open and minimally invasive surgical approaches result in comparable long-term cancer recurrence rates.
what the evidence does support
Surgical trauma can theoretically promote tumor recurrence in laboratory and animal models, but clinical trial evidence shows comparable long-term recurrence rates for open and minimally invasive surgeries.
Evidence for · 2
Sex disparity of liver cancer recurrence following surgery: sex-determining region Y gene promotes immunosuppressive microenvironment and favors metastasis
2025 · cited by 2
Mouse models demonstrate that surgical ischemia-reperfusion injury promotes tumor recurrence and metastasis by creating an immunosuppressive microenvironment.
Evidence against · 5
Five-Year Survival Outcomes of Laparoscopy-Assisted vs Open Distal Gastrectomy for Advanced Gastric Cancer: The JLSSG0901 Randomized Clinical Trial.
2023 · cited by 160
Randomized clinical trials comparing open surgery to minimally invasive laparoscopic approaches show no significant difference in 5-year relapse-free survival for advanced cancer.
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More for · 1
Epigenetic therapy inhibits metastases by disrupting premetastatic niches.
2020 · cited by 0
Surgical removal of primary tumors can trigger pathways and myeloid-derived suppressor cell accumulation that facilitate metastasis formation unless blocked by adjuvant therapy.
More against · 4
Advantage of laparoscopy surgery for elderly colorectal cancer patients without compromising oncologic outcome
2020 · cited by 22
Long-term cancer-specific survival and recurrence rates are similar between open and laparoscopic surgery cohorts in elderly colorectal cancer patients.
Short and long-term outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal and appendiceal cancer peritoneal metastasis: Propensity score-matched comparison between laparoscopy vs. open approaches.
2022 · cited by 11
Propensity score-matched comparisons reveal that the rate of early peritoneal loco-regional recurrence and 3-year survival outcomes are not related to whether an open or minimally invasive approach is used.
Laparoscopic vs open surgery for gastric cancer: Assessing time, recovery, complications, and markers
2024 · cited by 2
Studies on gastric cancer surgeries indicate that recurrence and long-term survival rates do not significantly differ between traditional open surgery and laparoscopic radical surgery.
Complicated Inguinocrural Hernias: Laparoscopic Vs. Open Surgery in the Emergency Setting
2025 · cited by 0
Emergency surgeries for complicated hernias show that minimally invasive and open approaches yield similar recurrence rates while maintaining safety.