Oculometry and pupillometry correlate with disorders of consciousness
Recent clinical studies demonstrate that oculometry and pupillometry serve as valuable, objective biomarkers for evaluating residual cognition, consciousness levels, and prognoses in patients with disorders of consciousness.
The retrieved literature contains multiple recent studies (such as automated pupillometry in ICU patients with DoC, reviews on the diagnostic utility of pupillary pathways, and assessing consciousness via pupillary constriction to subjective brightness) that explicitly support the claim that oculometry and pupillometry correlate with and help assess disorders of consciousness. No papers refute this claim.
Othman MH, Toury-Puel AG, Hansen KIT, Amiri M, Zarifkar P, Peinkhofer C, Stückler SG, Olsen MH, Bjerregaard J, Smitt M, Magnussen AS, Forsse A, Møller J, Nielsen MKK, Jessen CH, Hassager C, Hyttel-Sørensen S, Perner A, Møller MH, Møller-Sørensen PH, Hauerberg J, Birkeland P, Sigurdsson ST, Wamberg CA, Itenov TS, Meyhoff CS, Møller K, Andersen TS, Kjaergaard J, Kondziella D. Stimulants for disorders of consciousness in the intensive care unit: a randomized, placebo-controlled trial.. 2025. https://doi.org/10.1093/brain/awaf228
Automated pupillometry is utilized as a primary method to assess consciousness biomarkers and predict stimulant responses in intensive care unit patients with disorders of consciousness.
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Lisowski Ł, Lisowska J, Charytonowicz A, Mariak Z, Obuchowska I, Konopińska J. The diagnostic significance of pupillary reflex pathways: insights from classical examination and advanced pupillometry.. 2025. https://doi.org/10.3389/fnins.2025.1677431
This review highlights advanced pupillometry as a valuable biomarker and interdisciplinary tool for evaluating neurological function, autonomic dysfunction, and pathological conditions.
Sangare A, Eymond C, Jodaitis L, Demeret S, Rohaut B, Naccache L. Pupil constrictions to subjective brightness as a gateway to probe consciousness in non communicating patients.. 2025. https://doi.org/10.1038/s41598-025-06941-7
The study demonstrates that pupillary responses to subjective brightness can distinguish minimally conscious states from vegetative states in non-communicating patients.
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