Nucleophilic aromatic substitutions proceed via a stepwise or concerted mechanism
the verdict
SUPPORTED
the evidence backs this
confidence 78/100
Nucleophilic aromatic substitutions (S_NAr) can proceed through either a concerted or a stepwise mechanism depending on the substrate structure, nucleophile, and reaction conditions.
Evidence for · 3
Sulfonylation of Five‐Membered Aromatic Heterocycles Compounds through Nucleophilic Aromatic Substitution: Concerted or Stepwise Mechanism?
2020 · cited by 2
Paper [3] explicitly examines both concerted and stepwise mechanisms for nucleophilic aromatic substitution reactions, noting that different conditions dictate which pathway is followed.
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More for · 2
A mechanistic continuum of nucleophilic aromatic substitution reactions with azole nucleophiles.
2025 · cited by 1
Paper [4] discusses how S_NAr reactions can exist on a mechanistic continuum encompassing both stepwise and concerted pathways depending on substrate structure and conditions.
Substituent Effect on the Nucleophilic Aromatic Substitution of Thiophenes With Pyrrolidine: Theoretical Mechanistic and Reactivity Study.
2025 · cited by 1
Paper [8] details an S_NAr reaction that proceeds via a well-defined stepwise pathway involving a Meisenheimer-type intermediate.