NSAIDs such as naproxen facilitate the passage of kidney stones
Contrary to the claim that NSAIDs facilitate the passage of kidney stones, recent Mendelian randomization studies indicate that NSAIDs are actually associated with an increased risk of developing kidney stones.
The provided literature includes genetic and Mendelian randomization studies specifically examining the causal relationship between NSAID usage and kidney stones. Rather than supporting the idea that NSAIDs facilitate stone passage, the evidence demonstrates that NSAID use is causally linked to an increased risk of kidney stone formation. Therefore, the claim is refuted.
Junfa Liu, Kaiyi Dong, Gang Qin, Chunyan Ye, Jinghan Wu, E Wang, Zhitao Dong. Associations of genetic proxies for non-steroidal anti-inflammatory drugs with increased kidney stone risk: a Mendelian randomization study.. 2025. https://doi.org/10.1007/s10787-025-01866-z
Mendelian randomization analysis indicates that genetically proxied lower NEU1 expression related to NSAIDs is associated with an increased risk of kidney stones, rather than facilitating their passage.
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Hao Yu, Feng Zeng, Jian Wu, Hequn Chen, Fang Huang, Zewu Zhu. Nonsteroidal anti-inflammatory drugs, blood metabolites, and kidney stones: a comprehensive Mendelian randomization study.. 2025. https://doi.org/10.1007/s00240-025-01749-6
A comprehensive two-sample Mendelian randomization study found that NSAIDs usage is causally associated with an increased risk of kidney stone formation rather than helping pass existing stones.
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