Non-antigenic organs can be engineered for transplantation
the verdict
SUPPORTED
the evidence backs this
confidence 75/100
Recent advances in genetic engineering and gene-editing technologies have successfully reduced the antigenicity of animal organs, making xenotransplantation a viable and actively developing strategy for addressing human organ shortages.
Evidence for · 5
Genetic modification of pigs as organ donors for xenotransplantation.
2010 · cited by 0
Genetic modification of donor pigs enables the reduction of xenoantigens to overcome hyperacute rejection.
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More for · 4
Immune modulation in xenotransplantation.
2015 · cited by 0
Advances in genetic engineering facilitate the incorporation of human regulatory genes to lower xenotransplant immunogenicity.
Production and Functional Verification of 8-Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-Edited Donor Pigs for Xenotransplantation.
2025 · cited by 0
Multi-gene edited donor pigs successfully alleviate immune rejection and support organ function in xenotransplantation.
Current Techniques of Gene Editing in Pigs for Xenotransplantation.
2025 · cited by 0
Genetic engineering allows pig organs and tissues to be made less immunogenic by eliminating specific antigens.
Xenotransplantation of decellularized pig heart valves-Regulatory aspects in Europe.
2020 · cited by 0
Genetic modification of animal donors generates organs and tissues with significantly reduced antigenicity.