Nicotine worsens Crohn's disease symptoms

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Evidence consistently indicates that tobacco smoking and nicotine delivery systems negatively impact clinical outcomes and disease progression in Crohn's disease.

The analysis

The claim that nicotine worsens Crohn's disease symptoms is supported by literature showing that tobacco smoking negatively impacts disease outcomes (Paper 0) and that nicotine delivery systems such as e-cigarettes are associated with worse postoperative endoscopic recurrence in Crohn's disease patients (Paper 5). None of the retrieved papers refute this relationship.

Evidence for · 2

Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies.

Recorded source metadata

Caron B, Honap S, Peyrin-Biroulet L. Epidemiology of Inflammatory Bowel Disease across the Ages in the Era of Advanced Therapies.. 2024. https://doi.org/10.1093/ecco-jcc/jjae082

The review notes that smoking has consistently been shown to negatively impact disease outcomes for Crohn's disease.

Source citation format

See more details

More for · 1

Electronic Nicotine Delivery Systems and Clinical Outcomes in Adults With Inflammatory Bowel Disease: A Systematic Review of Emerging Evidence.

Recorded source metadata

Ahmed H, Almahmood M, Short A, Gomaa S, Abdelrazeq KS, Shahzad A, Alharethi A, Elsokary K, Mansour MK, Marshall J. Electronic Nicotine Delivery Systems and Clinical Outcomes in Adults With Inflammatory Bowel Disease: A Systematic Review of Emerging Evidence.. 2026. https://doi.org/10.7759/cureus.108605

The systematic review indicates that e-cigarette use is associated with a signal for higher postoperative endoscopic recurrence in Crohn's disease.

Source citation format

The paper trail · every fact has a biography

first checked02 Aug 2026

judged → SUPPORTED · 8802 Aug 2026

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