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the claim
Neurons maintain a negative resting potential due to ion concentration gradients and permeability
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
3 sources for · 0 against

Multiple studies demonstrate that neurons and other excitable cells maintain their negative resting membrane potential through established ion concentration gradients and selective membrane permeability.

Evidence for · 3
Sodium and potassium fluxes and membrane potential of human neutrophils: evidence for an electrogenic sodium pump
1982 · cited by 73
Demonstrates that resting membrane potential and ion fluxes in cells depend on sodium and potassium concentrations and permeability.
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The analysis

The claim is specific, empirical, and falsifiable. Papers [1], [6], and [10] directly support the physiological principles that ion concentration gradients (such as potassium and sodium) and membrane permeability govern the resting membrane potential. No papers refute this well-established consensus in neurophysiology.

More for · 2
The Effect of Calcium Ions on Resting Membrane Potential
2024 · cited by 6
Illustrates how ion distributions and movements, such as potassium leak channels and calcium/sodium dynamics, establish and modulate the resting membrane potential.
Activity-Dependent Fluctuations in Interstitial [K+]: Investigations Using Ion-Sensitive Microelectrodes
2023 · cited by 3
Shows that neuronal resting membrane potential is maintained and restored via potassium ion concentration gradients and efflux.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. General Principles for Measuring Resting Membrane Potential and Ion Concentration Using Fluorescent Bioelectricity Reporterspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Sodium and potassium fluxes and membrane potential of human neutrophils: evidence for an electrogenic sodium pumppeer-reviewedsupports
  3. Bioinspired ion-shuttling memristor with both neuromorphic functions and ion selectivity.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Mitochondrial membrane potential and compartmentalized signaling: Calcium, ROS, and beyond.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Protonic conductor: better understanding neural resting and action potential.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. The Effect of Calcium Ions on Resting Membrane Potentialpeer-reviewedsupports
  8. Advances in magnetic field approaches for non-invasive targeting neuromodulation.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. The Pseudomonas aeruginosa Tse4 toxin assembles ion-selective and voltage-sensitive ion channels to couple membrane depolarisation with K+ efflux.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. Lee's "Transmembrane Electrostatically-Localized Proton" model does NOT offer a better understanding of neuronal transmembrane potentials.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Activity-Dependent Fluctuations in Interstitial [K+]: Investigations Using Ion-Sensitive Microelectrodespeer-reviewedsupports
  12. Physiological Muscle Function Is Controlled by the Skeletal Endocannabinoid System in Murine Skeletal Muscles.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 8705 Aug 2026
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