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the claim
Neural connectivity strongly correlates with neurological function
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
8 sources for · 0 against

Multiple neuroimaging and clinical studies demonstrate that structural and functional neural connectivity metrics strongly correlate with and predict neurological and cognitive function.

Evidence for · 8
Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study
2010 · cited by 293
Paper 0 demonstrates that white matter tract integrity explains age-related declines in specific cognitive functions.
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The analysis

The retrieved papers consistently provide empirical evidence supporting the claim that neural connectivity (whether structural white matter integrity, gray matter microstructure, or structure-function coupling) strongly correlates with neurological and cognitive function across normal aging, neurodegenerative diseases, traumatic brain injury, and psychiatric disorders. All relevant papers support the relationship, and none refute it.

More for · 7
Relating structural and functional anomalous connectivity in the aging brain via neural mass modeling
2010 · cited by 60
Paper 1 shows how structural and functional connectivity changes link to neurological disorders like Alzheimer's disease and mild cognitive impairment.
Structural constraints of functional connectivity drive cognitive impairment in the early stages of multiple sclerosis
2020 · cited by 50
Paper 2 finds that structural-functional coupling in multiple sclerosis drives cognitive worsening and clinical disability.
Neural precursor cells tune striatal connectivity through the release of IGFBPL1
2022 · cited by 15
Paper 5 reveals that neural precursor cells tune striatal connectivity and support cognitive and behavioral functions.
A Novel Integration of Brain Structural and Functional Connectivity for Identifying Traumatic Brain Injury Induced Perturbations
2025 · cited by 8
Paper 7 establishes that structural and functional connectivity integration successfully models brain responses and disruptions from traumatic brain injury.
A history of traumatic brain injury is associated with poorer cognition and imaging evidence of altered white matter tract integrity in UK Biobank (n = 50 376)
2024 · cited by 4
Paper 8 finds that alterations in white matter tract integrity strongly inter-correlate with poorer cognitive performance following traumatic brain injury.
Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity
2025 · cited by 3
Paper 9 shows that plasma biomarkers of myelin integrity significantly correlate with white matter fibre tract density and cognitive performance in frontotemporal dementia.
Gray matter microstructure alterations with excess extra-cellular free water contribute to cognitive dysfunction in bipolar disorder: A comparative analysis with white matter pathology
2025 · cited by 2
Paper 10 demonstrates that gray and white matter microstructure alterations and free-water metrics directly contribute to cognitive dysfunction in bipolar disorder.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 9004 Aug 2026
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